Meta-analysis reveals gender difference in the association of liver cancer incidence and excess BMI
| Autor: | Ming Ma, Hui-Ling Chen, Kun-Fang Yao, Qiang Chen, Li-Shun Wang, Bing Han, Zhan-Ming Li, Xin-Quan Jiang, Guo-Yong Ding |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Gerontology medicine.medical_specialty business.industry Incidence (epidemiology) medicine.disease Body weight Obesity Confidence interval liver cancer 03 medical and health sciences BMI 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Internal medicine Meta-analysis Relative risk incidence Medicine business Liver cancer Body mass index Meta-Analysis |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Excess body weight has a positive association with risk of liver cancer, but the gender difference in the relationship between body mass index and liver cancer risk remains uncertainty. In this work, we performed meta-analysis for excess body weight and risk of liver cancer incidence to identify the gender difference. We searched the English-languages database and the Chinese literature databases to May 12, 2017. Overall, a total of 17 studies were included. Relative risks (RRs) with 95% confidence intervals was used to evaluate the strength of these associations. The RRs of liver cancer incidence for obese men and women were 2.04 (1.70-2.44) and 1.56 (1.37-1.78). The former one was significantly higher than the later one (P for interaction = 0.02). Notably, the RR of liver cancer incidence in non-Asian obese men was even higher than their counter part (2.31(1.85-2.91) vs. 1.56 (1.31-1.86), P for interaction = 0.01). Similar gender difference was observed in the dose-response curve. As example, at the point of BMI = 32 kg/m2, the RRs for men and women were 1.61 (1.45-1.79) and 1.41 (1.02-1.94) respectively. Findings from this meta-analysis indicate that obesity is associated with a higher risk of liver cancer incidence in men, especially in non-Asian men, which might partially contribute to the male dominance of liver cancer incidence. |
| Databáze: | OpenAIRE |
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