Thiols: Role in Oxidative Stress-Related Disorders
| Autor: | Volkan Gelen, Abdulsamed Kükürt, Mahmut Karapehlivan, Ömer Faruk Başer, Haci Ahmet Deveci |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Chemistry InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL medicine.disease_cause 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology 030220 oncology & carcinogenesis Internal medicine medicine GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Oxidative stress |
| Popis: | The effects of oxidative stress occur as a result of peroxidative damage of the macromolecule and membranes of the cells and with the disruption of metabolic activities in the components of the cells in living organisms. Organ and tissue pathologies are known to occur when oxidative stress is excessive in the body. It is known that thiols are one of the main protective mechanisms of the body against oxidative stress. Thiols have been shown to play important roles in enzymatic reactions, apoptosis, detoxification and antioxidant protection in the body. Many studies have shown changes in thiol status and thiol/disulphide homeostasis in various diseases such as digestive system, respiratory system, reproductive system, urinary system, metabolic diseases and cancer. This also shows that the thiol state is very important in the pathogenesis of oxidative stress-mediated diseases. Therefore, it is thought that interventions that can improve thiol status may contribute to the prevention or treatment of oxidative stress-related diseases. |
| Databáze: | OpenAIRE |
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