Melanotic neuroectodermal tumour of infancy: A report of two cases☆
| Autor: | Shady A. Moussa, Soad Mansour, Fahmy A. Mobarak, Mohamed Elsayed |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Wide excision animal structures medicine.medical_treatment Safety margin Article 03 medical and health sciences 0302 clinical medicine Medicine Head and neck Benign lesions Neoadjuvant therapy business.industry Gold standard Surgical excision Microscopic level 030206 dentistry Melanotic neuroectodermal tumour Maxillofacial pathology 030220 oncology & carcinogenesis embryonic structures Melanotic neuroectodermal tumour of infancy Surgery Radiology business High recurrence rate |
| Zdroj: | International Journal of Surgery Case Reports |
| ISSN: | 2210-2612 |
| Popis: | Highlights • Shedding light on the aggressive nature and rare incidence of Melanotic Neuroectodermal Tumour of Infancy (MNTI). • Detailing different clinical and radiographic features of MNTI. • Outlining the management of MNTI and postoperative follow-up regimen. • Emphasising the importance of early diagnosis and surgical intervention in Melanotic Neuroectodermal Tumour of Infancy. Introduction Melanotic neuroectodermal tumour of infancy (MNTI) is a benign tumour of infancy, most commonly affecting the head and neck region. First described in 1918, less than 500 cases have been reported in the literature. MNTI is aggressive in nature & has a high rate of recurrence. Presentation of cases In this retrospective case series, we report two cases of MNTI that presented at our unit; both cases were managed by wide excision and have been followed up uneventfully for over two years. Discussion MNTI has a recurrence rate of up to 20%. Patient’s age can play a significant role in recurrence rate. Although this neural crest tumour is somewhat rare in the literature, there is a consensus with regards to surgical management; the gold standard remains to be wide excision with safety margin. Select cases may benefit from adjuvant and neoadjuvant therapy. Conclusion Owing to its locally aggressive nature and high recurrence rate, prompt diagnosis and surgical intervention is advised in cases of MNTI. Further understanding of this tumour is needed on a microscopic level in order to determine clear prognostic factors. |
| Databáze: | OpenAIRE |
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