Switching from Tacrolimus to Sirolimus Halts the Appearance of New Sebaceous Neoplasmsin Muir-Torre Syndrome
| Autor: | Eyal Gal, I. Kedar-Barnes, Eytan Mor, Zohar Levi, Rachel Hazazi, E. Hodak, Yaron Niv, J. Winkler |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adenoma
Male medicine.medical_specialty Pathology medicine.medical_treatment Liver transplantation Tacrolimus Muir–Torre syndrome Humans Immunology and Allergy Medicine Pharmacology (medical) Sebaceous Gland Neoplasms Antibacterial agent Immunosuppression Therapy Sirolimus Transplantation business.industry Immunosuppression Syndrome Middle Aged equipment and supplies medicine.disease Colorectal Neoplasms Hereditary Nonpolyposis Kidney Transplantation Dermatology Calcineurin Regimen MutS Homolog 2 Protein surgical procedures operative Mutation Disease Progression business Immunosuppressive Agents medicine.drug |
| Zdroj: | American Journal of Transplantation. 7:476-479 |
| ISSN: | 1600-6135 |
| DOI: | 10.1111/j.1600-6143.2006.01648.x |
| Popis: | Little is known about the effects of immunosuppression on patients with hereditary nonpolyposis colorectal cancer (HNPCC). We describe a kidney transplant recipient with unrecognized Muir-Torre syndrome in whom the administration of a tacrolimus-based regimen led to the eruption of multiple sebaceous tumors. The patient was later found to harbor an MSH2 mutation. Switching to a sirolimus-based regimen resulted in arrest of the disease. When the patient was switched back to tacrolimus, new facial lesions rapidly appeared. Switching again to sirolimus resulted again in halting the appearance of new lesions. This finding is in line with the known antiangiogenic activity of sirolimus and reports on the regression of cutaneous Kaposi's sarcoma in kidney transplant recipients switched from another immunosuppressive regimen to sirolimus. Further studies on the potential use of sirolimus for the treatment of de novo tumors in immunosuppressed kidney transplant recipients with HNPCC are warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text