Penpolonin A-E, cytotoxic α-pyrone derivatives from Penicillium polonicum
| Autor: | Yeerlan Bahetejiang, Chaoqun Wu, Xinzhou Yang, Yanzhang Wen, Haitao Cheng, Jingtong Deng, Kejian Pang, Huiqi Huang, Yu Peng, Yuanren Ma |
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| Rok vydání: | 2020 |
| Předmět: |
Stereochemistry
Clinical Biochemistry Pharmaceutical Science Antineoplastic Agents 01 natural sciences Biochemistry Plant Roots chemistry.chemical_compound Cell Line Tumor Drug Discovery Camptotheca Ic50 values Cytotoxic T cell Humans Cytotoxicity Molecular Biology 010405 organic chemistry Chemistry Organic Chemistry Penicillium Endophytic fungus Pyrone 0104 chemical sciences Penicillium polonicum 010404 medicinal & biomolecular chemistry Cell culture Pyrones Cancer cell Molecular Medicine Drug Screening Assays Antitumor |
| Zdroj: | Bioorganicmedicinal chemistry letters. 40 |
| ISSN: | 1464-3405 |
| Popis: | Five new α-pyrone derivatives, named penpolonin A–E (1–5), together with two known compounds (6–7) were acquired from the endophytic fungus Penicillium polonicum isolated from the roots of Camptotheca acuminata Decne. Their structures were established by combination of NMR and HRESIMS data and the absolute configurations of 1–5 were determined by NMR calculations and comparison of experimental and calculated ECD data. Compounds 3 and 7 exhibited moderate cytotoxicity against Hep-2, TU212 human laryngeal cancer cells with IC50 values ranging from 31.6 to 45.1 μg/ml, compound 4 showed weak cytotoxicity against the Hep-2 and TU212 cell lines with IC50 values of 69.2 and 68.7 μg/ml. |
| Databáze: | OpenAIRE |
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