Dihydroartemisinin Induces Ferroptosis in HCC by Promoting the Formation of PEBP1/15-LO
| Autor: | Ying Su, Danli Zhao, Chun Jin, Zhanghao Li, Sumin Sun, Siwei Xia, Yuxin Zhang, Zili Zhang, Feng Zhang, Xuefen Xu, Jiangjuan Shao, Biyun Zhang, Shizhong Zheng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Aging Carcinoma Hepatocellular Article Subject Mice Nude Apoptosis Phosphatidylethanolamine Binding Protein Biochemistry Antimalarials Mice Tumor Cells Cultured Animals Arachidonate 15-Lipoxygenase Ferroptosis Humans Cell Proliferation Mice Inbred BALB C QH573-671 Liver Neoplasms food and beverages Cell Biology General Medicine Xenograft Model Antitumor Assays Artemisinins Gene Expression Regulation Neoplastic lipids (amino acids peptides and proteins) Cytology Research Article |
| Zdroj: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2021 (2021) |
| ISSN: | 1942-0994 1942-0900 |
| Popis: | Relevant researches have recognized the vital role of inducing ferroptosis in the treatment of tumor. The latest findings indicate that PEBP1/15-LO can play an essential role in the process of cell death. However, its role in regulating ferroptosis in hepatocellular carcinoma (simplified by HCC) remains unclear. The previous research of our team has proved that DHA can induce ferroptosis of hepatic stellate cells. In this study, we found that DHA could also induce ferroptosis in HCC cells. Interestingly, DHA induced ferroptosis by promoting the formation of PEBP1/15-LO and promoting cell membrane lipid peroxidation. In addition, we also found that DHA had no obvious regulatory effect on 15-LO, but it could promote PEBP1 protein expression. Importantly, we discovered the upregulation of PEBP1 induced by DHA was related to the inhibition of its ubiquitination degradation. In vivo experiments have also obtained consistent results that DHA can inhibit tumor growth and affect the expression of ferroptosis markers in tumor tissues, which would be partially offset by interference with PEBP1. |
| Databáze: | OpenAIRE |
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