A novel Ag/carrageenan–gelatin hybrid hydrogel nanocomposite and its biological applications: Preparation and characterization
| Autor: | V. Sivaranjani, Kunnathur Murugesan Sakthivel, Catalin I. Pruncu, U. Pavithra, N. Balasubramanian, L. Muthulakshmi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Silver
Materials science food.ingredient Biocompatibility Scanning electron microscope Biomedical Engineering Metal Nanoparticles 02 engineering and technology Carrageenan Gelatin Silver nanoparticle Nanocomposites Biomaterials 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine food X-Ray Diffraction Spectroscopy Fourier Transform Infrared Escherichia coli Humans Fourier transform infrared spectroscopy Hydrogels 030206 dentistry 021001 nanoscience & nanotechnology Anti-Bacterial Agents Chemical engineering chemistry Mechanics of Materials Transmission electron microscopy Microscopy Electron Scanning Glutaraldehyde 0210 nano-technology |
| Zdroj: | Journal of the Mechanical Behavior of Biomedical Materials. 115:104257 |
| ISSN: | 1751-6161 |
| DOI: | 10.1016/j.jmbbm.2020.104257 |
| Popis: | A novel biohybrid hydrogel nanocomposite made of natural polymer carrageenan and gelatin protein were developed. The silver nanoparticles were prepared using the carrageenan polymer as reduction and capping agent. Here, the Ag/Carrageenan was combined with gelatin hydrogel using glutaraldehyde having a cross-link role in order to create the biohybrid hydrogel nanocomposite. The manufactured composite performances were anaylised by UV-visible spectroscopy, Fourier Transform infrared (FTIR) spectroscopy, Scanning Electron Microscopy (SEM), Energy dispersive X-ray (EDX) spectroscopy and Transmission Electron Microscopy (TEM) methods. The swelling behaviour of the Ag/Carrageenan-gelatin hybrid hydrogel nanocomposite was also analyzed. The antibacterial activity was tested against human pathogens viz. S.agalactiae 1661, S. pyogenes 1210 and E. coli. The bacterial cell wall damage of S.agalactiae 1661 was analyzed by scanning electron microscopy. The cytotoxic assay was performed against the A549 lung cancer cells. |
| Databáze: | OpenAIRE |
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