OXA-23 and OXA-40 producing carbapenem-resistant Acinetobacter baumannii in Central Illinois
| Autor: | Udita Chapagain, Vidya Sundareshan, Lohitha Guntupalli, Yohei Doi, Sameena Koirala, Jerry Lawhorn, Janak Koirala, Christopher Quarshie, Sami Akram, Michael E. Olson, Isha Tyagi, Sajan Koirala |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Acinetobacter baumannii Carbapenem 030106 microbiology Microbial Sensitivity Tests beta-Lactamases Microbiology Tertiary Care Centers 03 medical and health sciences 0302 clinical medicine Bacterial Proteins Drug Resistance Multiple Bacterial polycyclic compounds medicine Humans 030212 general & internal medicine Carbapenem resistance biology General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Anti-Bacterial Agents Infectious Diseases Carbapenems bacteria Illinois Carbapenem resistant Acinetobacter baumannii medicine.drug Acinetobacter Infections |
| Zdroj: | Diagnostic microbiology and infectious disease. 97(1) |
| ISSN: | 1879-0070 |
| Popis: | We reviewed susceptibility of 840 A. baumannii complex isolates at two academic medical centers and explored their mechanism of carbapenem resistance. Carbapenem resistance rates among A. baumannii increased from 2 μg/mL). Phenotypic screening showed carbapenemase production in 50 isolates, but none was positive for MBL. Among carbapenem non-susceptible isolates, the CHDL (group D carbapenemase) encoding genes blaOXA-23 (52%) and blaOXA-40 (28%) were the most frequent genes. In conclusion, carbapenem resistance rates in A. baumannii peaked in 2011 and have since declined in our region. Carbapenem resistance among A. baumannii was primarily associated with production of acquired CHDLs including OXA-23 and OXA-40. |
| Databáze: | OpenAIRE |
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