THE METABOLIC EFFECTS OF THIAZIDE THERAPY IN THE ELDERLY: A POPULATION STUDY
| Autor: | Peter Cumber, Michael Petri, David Treby, David Rawlins, Harmut Ising, Richard A. Bryant, Lindsey Grimes |
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| Rok vydání: | 1986 |
| Předmět: |
Blood Glucose
Male Aging medicine.medical_specialty medicine.medical_treatment Hypokalemia Hypomagnesemia Internal medicine medicine Humans Magnesium Thiazide Aged Plasma glucose business.industry Sodium General Medicine medicine.disease humanities Endocrinology Bendroflumethiazide Metabolic effects Potassium Population study Female Potassium deficiency Geriatrics and Gerontology medicine.symptom Diuretic business medicine.drug |
| Zdroj: | Age and Ageing. 15:151-155 |
| ISSN: | 1468-2834 0002-0729 |
| DOI: | 10.1093/ageing/15.3.151 |
| Popis: | The metabolic consequences of thiazide diuretics are well known. The elderly to whom these agents are widely prescribed may be particularly susceptible. To quantify this metabolic risk, plasma and intracellular electrolytes and plasma glucose were measured in the elderly population of a Somerset village. Highly significant reductions in both plasma and cellular magnesium and potassium were found in the 47 thiazide-treated people. Forty-eight per cent of the thiazide-treated group were hypomagnesaemic and 28% were hypokalaemic. Thus, magnesium and potassium depletion are commonly associated with thiazide therapy in the elderly. These metabolic effects should be considered carefully prior to the use of these agents. |
| Databáze: | OpenAIRE |
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