Oral ethanol reinforcement in the rat: effects of acute amphetamine
| Autor: | Herman H. Samson, Anne O. Pfeffer |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
Health (social science) Dextroamphetamine Pharmacology Toxicology Body weight Biochemistry Behavioral Neuroscience chemistry.chemical_compound Long evans rats Catecholamines medicine Animals Reinforcement Amphetamine Brain Chemistry Ethanol business.industry General Medicine Drug vehicle Rats Food restriction Neurology chemistry Catecholamine Conditioning Operant business Food Deprivation Reinforcement Psychology medicine.drug |
| Zdroj: | Alcohol (Fayetteville, N.Y.). 2(5) |
| ISSN: | 0741-8329 |
| Popis: | Six male Long Evans rats, reduced to 80% body weight by food restriction, were trained to lever press using 5% ethanol and water reinforcement on a concurrent FR8 FR8 schedule. After responding had stabilized, d-amphetamine (0.25 mg/kg, 0.50 mg/kg, and 1.00 mg/kg) or drug vehicle was injected 15 minutes before the 30-minute sessions. In comparison with the vehicle injections, the 0.25 mg/kg amphetamine dose was followed by a nonsignificant trend towards increased ethanol responding, the 0.50 mg/kg dose produced no trend, and the 1.00 mg/kg dose significantly decreased ethanol responding. These effects resemble those of amphetamine on food responding by food-deprived rats. Since both ethanol and amphetamine act upon brain catecholamine systems, possible involvement of catecholamines in reinforcement and arousal was discussed in relation to these results. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|