Fabrication of micro-patterned substrates for plasmonic sensing by piezo-dispensing of colloidal nanoparticles
Autor: | Norman Grosse, Ondrej Stranik, Angelina Pittner, Wolfgang Fritzsche, Sebastian Wendt, David Zopf, Andrea Csáki, André Dathe |
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Rok vydání: | 2019 |
Předmět: |
Fabrication
Materials science 010401 analytical chemistry Nanoparticle Nanotechnology 02 engineering and technology Substrate (electronics) 021001 nanoscience & nanotechnology 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry Micrometre Nanolithography 0210 nano-technology Wet chemistry Plasmon Protein adsorption |
Zdroj: | Analytical and Bioanalytical Chemistry. 411:1537-1547 |
ISSN: | 1618-2650 1618-2642 |
Popis: | In this work we describe a very fast and flexible method for fabrication of plasmon-supporting substrates with micro-patterning capability, which is optimized for plasmonic sensing. We combined a wet chemistry approach to synthesize metallic nanoparticles with a piezo-dispensing system enabling deposition of nanoparticles on the substrates with micrometer precision. In this way, an arbitrary pattern consisting of 200 μm small spots containing plasmonic nanostructures can be produced. Patterns with various nanoparticles exhibiting different plasmonic properties were combined, and the surface density of the particles could be easily varied via their solution concentrations. We showed that under controlled conditions the dispensing process caused no aggregation of the particles and it enabled full transfer of the colloidal solutions onto the substrate. This is an important condition, which enables these substrates to be used for reliable plasmonic sensing based on monitoring the spectral shift of the nanoparticles. We demonstrated the functionality of such substrates by detection of small protein adsorption on the spots based on plasmon label-free sensing method. |
Databáze: | OpenAIRE |
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