| Popis: |
Ohinska Nataliia, Nebesna Zoia, Kramar Solomiia. Modern ideas about morphological changes in the cerebellar cortex under influence of factors of different origin. Journal of Education, Health and Sport. 2020;10(2):368-374. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.02.041 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.02.041 https://zenodo.org/record/4618612 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 31.01.2020. Revised: 10.02.2020. Accepted: 28.02.2020. MODERN IDEAS ABOUT MORPHOLOGICAL CHANGES IN THE CEREBELLAR CORTEX UNDER INFLUENCE OF FACTORS OF DIFFERENT ORIGIN Nataliia Ohinska, Zoia Nebesna, Solomiia Kramar I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine Department of Histology and Embryology Nataliia Ohinska: https://orcid.org/0000-0003-4398-8744; ohinska@tdmu.edu.ua; corresponding author Zoia Nebesna: https://orcid.org/0000-0002-6869-0859; nebesna_zm@tdmu.edu.ua Solomiia Kramar: https://orcid.org/0000-0003-3654-4950; kramarsb@tdmu.edu.ua Abstract The work is a fragment of scientific research “Peculiarities of structural reorganization of the nervous, digestive, endocrine systems, hematopoietic and immune organs under conditions of thermal injury and the use of corrective factors” (0120U104152). The study of the state of internal organs and systems of the body under the influence of external factors that are stressful is relevant. The negative impact of environmental factors on the central nervous system, including cerebellum, leads to their structural and functional restructuring. The cerebellum is a multifunctional component of the brain and the object of numerous lesions. The purpose of this work is analysis of scientific literature which is dedicated study of the influence of exogenous and endogenous factors on the morphological structure of the cerebellum. The article analyzes the scientific literature of the effects of hypodynamia, hypothermia, hypokinesia, alcohol intoxication, toxic effects of Lead, drugs, pharmacological agents, low-frequency pulsed electromagnetic field on the micro- and submicroscopic organization of the cerebellum. In lots of experimental studies, which were analyzed it is established that in the dynamics of the influence of different factors there is a reorganization of the cerebellar cortex layers and disruption of the microcirculatory bed structures. Purkinje cells change shape to spherical, their processes are thinned, sharply hyperchromic neurocytes prevail over normochromic ones. The functional activity of neurons is reduced, because the chromatophilic substance is almost absent. The thickness of the molecular and granular layers decreases. The ganglionic layer loses its single-row arrangement of neurons. There are erythrocytes in the coin columns in the lumens of hemocapillaries. The dilatation and prevascular edema are observed. Thus, under the conditions of negative influence of various factors in neurocytes of a cerebellar cortex and links of a microcirculatory channel there are destructive and degenerative changes on micro- and submicroscopic levels. In the long run there are adaptive-compensatory processes and necrotic, which had a phase dependence. So, destructive and degenerative changes on micro- and submicroscopic levels. In the long run there are adaptive-compensatory processes and necrotic, which had a phase dependence. Key words: cerebellum; neurons; micro- and submicroscopic changes; exogenous and endogenous effects. |
