Association of Host Factors With Antibody Response to Seasonal Influenza Vaccination in Allogeneic Hematopoietic Stem Cell Transplant Patients
| Autor: | Antonia M.S. Müller, Hans-Michael Kaltenbach, Dominik Vogt, Nathan Cantoni, Jörg Halter, J. Linnik, Georg Stussi, Jörg Stelling, Mohammedyaseen Syedbasha, Urs Schanz, Maja Weisser, Thomas Pabst, Yvonne Hollenstein, Sabine Ruosch-Girsberger, Lukas Kaufmann, Adrian Egli |
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| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_treatment
610 Medicine & health Hematopoietic stem cell transplantation Booster dose Antibodies Viral categorical regression Cohort Studies Influenza A Virus H1N1 Subtype Influenza Human graft-versus-host disease Humans Immunology and Allergy Medicine Seroconversion seroconversion immunosuppression business.industry Influenza A Virus H3N2 Subtype Immunosuppression vaccination medicine.disease hemagglutination inhibition titer Transplantation Vaccination Calcineurin Infectious Diseases Graft-versus-host disease Influenza Vaccines Antibody Formation Immunology Seasons sequential model influenza business |
| Zdroj: | The Journal of Infectious Diseases, 225 (8) Linnik, Janina; Syedbasha, Mohammedyaseen; Kaltenbach, Hans-Michael; Vogt, Dominik; Hollenstein, Yvonne; Kaufmann, Lukas; Cantoni, Nathan; Ruosch-Girsberger, Sabine; Müller, Antonia M S; Schanz, Urs; Pabst, Thomas; Stüssi, Georg; Weisser, Maja; Halter, Jörg; Stelling, Jörg; Egli, Adrian (2022). Association of Host Factors With Antibody Response to Seasonal Influenza Vaccination in Allogeneic Hematopoietic Stem Cell Transplant Patients. The journal of infectious diseases, 225(8), pp. 1482-1493. Oxford University Press 10.1093/infdis/jiab391 |
| ISSN: | 0346-7074 0022-1899 1537-6613 |
| DOI: | 10.48350/174435 |
| Popis: | Background Influenza vaccination efficacy is reduced after hematopoietic stem cell transplantation (HSCT) and patient factors determining vaccination outcomes are still poorly understood. Methods We investigated the antibody response to seasonal influenza vaccination in 135 HSCT patients and 69 healthy volunteers (HVs) in a prospective observational multicenter cohort study. We identified patient factors associated with hemagglutination inhibition titers against A/California/2009/H1N1, A/Texas/2012/H3N2, and B/Massachusetts/2012 by multivariable regression on the observed titer levels and on seroconversion/seroprotection categories for comparison. Results Both regression approaches yielded consistent results but regression on titers estimated associations with higher precision. HSCT patients required 2 vaccine doses to achieve average responses comparable to a single dose in HVs. Prevaccination titers were positively associated with time after transplantation, confirming that HSCT patients can elicit potent antibody responses. However, an unrelated donor, absolute lymphocyte counts below the normal range, and treatment with calcineurin inhibitors lowered the odds of responding. Conclusions HSCT patients show a highly heterogeneous vaccine response but, overall, patients benefited from the booster shot and can acquire seroprotective antibodies over the years after transplantation. Several common patient factors lower the odds of responding, urging identification of additional preventive strategies in the poorly responding groups. Clinical Trials Registration NCT03467074. The Journal of Infectious Diseases, 225 (8) ISSN:0022-1899 ISSN:1537-6613 |
| Databáze: | OpenAIRE |
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