Noninvasive fractional flow reserve derived from coronary computed tomography angiography for identification of ischemic lesions:a systematic review and meta-analysis
| Autor: | Xiao-Min Ren, Dao-Rong Pan, Shao-Liang Chen, Nicolas Foin, Si Pang, Wen Wu, Aravinda Nanjundappa, Peng Ye, Jie Luo, Niels Ramsing Holm |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Computed Tomography Angiography Fractional flow reserve Coronary Artery Disease 030204 cardiovascular system & hematology Sensitivity and Specificity Article Coronary artery disease 03 medical and health sciences 0302 clinical medicine Odds Ratio Medicine Humans 030212 general & internal medicine Computed tomography angiography Aged Multidisciplinary medicine.diagnostic_test business.industry Odds ratio Gold standard (test) Middle Aged medicine.disease Confidence interval Fractional Flow Reserve Myocardial Meta-analysis Diagnostic odds ratio Female Radiology business |
| Zdroj: | Wu, W, Pan, D-R, Foin, N, Pang, S, Ye, P, Holm, N, Ren, X-M, Luo, J, Nanjundappa, A & Chen, S-L 2016, ' Noninvasive fractional flow reserve derived from coronary computed tomography angiography for identification of ischemic lesions : a systematic review and meta-analysis ', Scientific Reports, vol. 6, pp. 29409 . https://doi.org/10.1038/srep29409 Scientific Reports |
| DOI: | 10.1038/srep29409 |
| Popis: | Detection of coronary ischemic lesions by fractional flow reserve (FFR) has been established as the gold standard. In recent years, novel computer based methods have emerged and they can provide simulation of FFR using coronary artery images acquired from coronary computed tomography angiography (FFRCT). This meta-analysis aimed to evaluate diagnostic performance of FFRCT using FFR as the reference standard. Databases of PubMed, Cochrane Library, EMBASE, Medion and Web of Science were searched. Seven studies met the inclusion criteria, including 833 stable patients (1377 vessels or lesions) with suspected or known coronary artery disease (CAD). The patient-based analysis showed pooled estimates of sensitivity, specificity and diagnostic odds ratio (DOR) for detection of ischemic lesions were 0.89 [95%confidence interval (CI), 0.85–0.93], 0.76 (95%CI, 0.64–0.84) and 26.21 (95%CI, 13.14–52.28). At a per-vessel or per-lesion level, the pooled estimates were as follows: sensitivity 0.84 (95%CI, 0.80–0.87), specificity 0.76 (95%CI, 0.67–0.83) and DOR 16.87 (95%CI, 9.41–30.25). Area under summary receiver operating curves was 0.90 (95%CI, 0.87–0.92) and 0.86 (95%CI, 0.83–0.89) at the two analysis levels, respectively. In conclusion, FFRCT technology achieves a moderate diagnostic performance for noninvasive identification of ischemic lesions in stable patients with suspected or known CAD in comparison to invasive FFR measurement. |
| Databáze: | OpenAIRE |
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