Corollary discharge in precerebellar nuclei of sleeping infant rats
| Autor: | Didhiti Mukherjee, Greta Sokoloff, Mark S Blumberg |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Cerebellum Somatosensory system Synaptic Transmission Rats Sprague-Dawley Lateral reticular nucleus 0302 clinical medicine Corollary Biology (General) Precerebellar nuclei sensorimotor Neurons General Neuroscience General Medicine medicine.anatomical_structure Cerebellar Nuclei myoclonic twitch Potassium Channels Voltage-Gated Medicine Female REM sleep Brainstem Research Article cerebellum QH301-705.5 Science Sensory system Motor Activity Biology General Biochemistry Genetics and Molecular Biology Midbrain 03 medical and health sciences medicine Animals Muscle Skeletal General Immunology and Microbiology Rats 030104 developmental biology Animals Newborn inferior olive Rat lateral reticular nucleus Sleep Neuroscience 030217 neurology & neurosurgery Brain Stem |
| Zdroj: | eLife, Vol 7 (2018) eLife |
| ISSN: | 2050-084X |
| DOI: | 10.7554/elife.38213 |
| Popis: | In week-old rats, somatosensory input arises predominantly from external stimuli or from sensory feedback (reafference) associated with myoclonic twitches during active sleep. A previous study suggested that the brainstem motor structures that produce twitches also send motor copies (or corollary discharge, CD) to the cerebellum. We tested this possibility by recording from two precerebellar nuclei—the inferior olive (IO) and lateral reticular nucleus (LRN). In most IO and LRN neurons, twitch-related activity peaked sharply around twitch onset, consistent with CD. Next, we identified twitch-production areas in the midbrain that project independently to the IO and LRN. Finally, we blocked calcium-activated slow potassium (SK) channels in the IO to explain how broadly tuned brainstem motor signals can be transformed into precise CD signals. We conclude that the precerebellar nuclei convey a diversity of sleep-related neural activity to the developing cerebellum to enable processing of convergent input from CD and reafferent signals. |
| Databáze: | OpenAIRE |
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