| Autor: |
Shu Zhou, Jinjun Li, XiaoNa Zhang, Wen Xiong |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Bioengineered. 13(5) |
| ISSN: |
2165-5987 |
| Popis: |
Microglia activation-stimulated neuroinflammation exerts functionally in neurodegenerative diseases like brain injury. Acute methanol poisoning (AMP) is a crucial cause of death and morbidity that possibly leads to neuroinflammation. Studies have manifested that miRNAs can modulate microglia activation to mediate neuroinflammation. Nevertheless, the role of miR-124 in AMP-stimulated neuroinflammation is uncertain. This research was to explore the action of miR-124 in AMP-stimulated neuroinflammation and its molecular mechanism. The study findings indicated that AMP accelerated microglia activation and stimulated inflammation and oxidative stress in brain tissue of rats. MiR-124 expression was lowered in AMP rats, while KLF6 expression was elevated. Elevated miR-124 or repressed KLF6 increased the number of CD206 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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