Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases:protocol for a prospective cohort study of prognostic factors and personalised medicine

Autor:	Mette Boye, Jimmi Wied, Andre Franke, Henning Glerup, Tue Bjerg Bennike, Jacob Broder Brodersen, Jakob Grauslund, Ivan Brandslund, Jan Fallingborg, Ulrich Fredberg, Robin Christensen, Nils J. Færgeman, Steffen Thiel, Mohamad Jawhara, Vibeke Andersen, Anders Bojesen, Anette Bygum, Jens Frederik Dahlerup, Grith Lykke Sørensen, Jesper Frøjk, Torkell Ellingsen, Erik Berg Schmidt, Lars Werner, Jan Alexander Villadsen, Ole Haagen Nielsen, Philip Rosenstiel, Berit L. Heitmann, Søren Geill Kjær, Signe Bek Sørensen, David Ellinghaus, Lone Hvid, Uffe Holmskov, Charlotte Lindgaard Nielsen, Heidi Lausten Munk, Jeroen Raes, Karina Winther Andersen, Torben Knudsen, Anders Bathum Nexøe, Jens Kjeldsen, Seyed A G R Moghadd, Allan Stensballe
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Dietary Fiber Disease Inflammatory bowel disease 0302 clinical medicine lifestyle and chronic inflammatory disease Quality of life Protocol Hidradenitis suppurativa Prospective Studies 030212 general & internal medicine Precision Medicine Prospective cohort study Research Support Non-U.S. Gov't EUROPEAN PROSPECTIVE COHORT ANKYLOSING-SPONDYLITIS General Medicine biomarker and lifestyle personalized medicine Prognosis CROHNS-DISEASE Medical Management 3. Good health Meat Products ULCERATIVE-COLITIS SHORT HEALTH SCALE Research Design SULFATE-REDUCING BACTERIA 030211 gastroenterology & hepatology medicine.medical_specialty Skin Diseases Uveitis 03 medical and health sciences Psoriatic arthritis patient related outcome measures Rheumatic Diseases Internal medicine Psoriasis medicine Journal Article Humans Patient Reported Outcome Measures BOWEL-DISEASE Life Style LONG-TERM INTAKE FOOD FREQUENCY QUESTIONNAIRE Inflammation Tumor Necrosis Factor-alpha business.industry Inflammatory Bowel Diseases medicine.disease Comorbidity Diet RHEUMATOID-ARTHRITIS Red Meat Chronic Disease Quality of Life treatment outcome western style diet business
Zdroj:	Christensen, R, Heitmann, B L, Andersen, K W, Nielsen, O H, Sørensen, S B, Jawhara, M, Bygum, A, Hvid, L, Grauslund, J, Wied, J, Glerup, H, Fredberg, U, Villadsen, J A, Kjær, S G, Fallingborg, J, Moghadd, S A G R, Knudsen, T, Brodersen, J, Frøjk, J, Dahlerup, J F, Bojesen, A B, Sorensen, G L, Thiel, S, Færgeman, N J, Brandslund, I, Bennike, T B, Stensballe, A, Schmidt, E B, Franke, A, Ellinghaus, D, Rosenstiel, P, Raes, J, Boye, M, Werner, L, Nielsen, C L, Munk, H L, Nexøe, A B, Ellingsen, T, Holmskov, U, Kjeldsen, J & Andersen, V 2018, ' Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases : protocol for a prospective cohort study of prognostic factors and personalised medicine ', BMJ Open, vol. 8, no. 2, e018166 . https://doi.org/10.1136/bmjopen-2017-018166 Christensen, R, Heitmann, B L, Andersen, K W, Nielsen, O H, Sørensen, S B, Jawhara, M, Bygum, A, Hvid, L, Grauslund, J, Wied, J, Glerup, H, Fredberg, U, Villadsen, J A, Kjær, S G, Fallingborg, J, Moghadd, S A G R, Knudsen, T, Brodersen, J, Frøjk, J, Dahlerup, J F, Bojesen, A B, Sorensen, G L, Thiel, S, Færgeman, N J, Brandslund, I, Bennike, T B, Stensballe, A, Schmidt, E B, Franke, A, Ellinghaus, D, Rosenstiel, P, Raes, J, Boye, M, Werner, L, Nielsen, C L, Munk, H L, Nexøe, A B, Ellingsen, T, Holmskov, U, Kjeldsen, J & Andersen, V 2018, ' Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases : protocol for a prospective cohort study of prognostic factors and personalised medicine ', B M J Open, vol. 8, no. 2, e018166 . https://doi.org/10.1136/bmjopen-2017-018166 BMJ Open Christensen, R, Heitmann, B L, Andersen, K W, Nielsen, O H, Sørensen, S B, Jawhara, M, Bygum, A, Hvid, L, Grauslund, J, Wied, J, Glerup, H, Fredberg, U, Villadsen, J A, Kjær, S G, Fallingborg, J, Moghadd, S A G R, Knudsen, T, Brodersen, J, Frøjk, J, Dahlerup, J F, Bojesen, A B, Sørensen, G L, Thiel, S, Færgeman, N J, Brandslund, I, Bennike, T B, Stensballe, A, Schmidt, E B, Franke, A, Ellinghaus, D, Rosenstiel, P, Raes, J, Boye, M, Werner, L, Nielsen, C L, Munk, H L, Nexoe, A B, Ellingsen, T, Holmskov, U, Kjeldsen, J & Andersen, V 2018, ' Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases : protocol for a prospective cohort study of prognostic factors and personalised medicine ', BMJ Open, vol. 8, no. 2, :e018166 . https://doi.org/10.1136/bmjopen-2017-018166
Popis:	IntroductionChronic inflammatory diseases (CIDs) are frequently treated with biological medications, specifically tumour necrosis factor inhibitors (TNFi)). These medications inhibit the pro-inflammatory molecule TNF alpha, which has been strongly implicated in the aetiology of these diseases. Up to one-third of patients do not, however, respond to biologics, and lifestyle factors are assumed to affect treatment outcomes. Little is known about the effects of dietary lifestyle as a prognostic factor that may enable personalised medicine. The primary outcome of this multidisciplinary collaborative study will be to identify dietary lifestyle factors that support optimal treatment outcomes.Methods and analysisThis prospective cohort study will enrol 320 patients with CID who are prescribed a TNFi between June 2017 and March 2019. Included among the patients with CID will be patients with inflammatory bowel disease (Crohn’s disease and ulcerative colitis), rheumatic disorders (rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis), inflammatory skin diseases (psoriasis, hidradenitis suppurativa) and non-infectious uveitis. At baseline (pretreatment), patient characteristics will be assessed using patient-reported outcome measures, clinical assessments of disease activity, quality of life and lifestyle, in addition to registry data on comorbidity and concomitant medication(s). In accordance with current Danish standards, follow-up will be conducted 14–16 weeks after treatment initiation. For each disease, evaluation of successful treatment response will be based on established primary and secondary endpoints, including disease-specific core outcome sets. The major outcome of the analyses will be to detect variability in treatment effectiveness between patients with different lifestyle characteristics.Ethics and disseminationThe principle goal of this project is to improve the quality of life of patients suffering from CID by providing evidence to support dietary and other lifestyle recommendations that may improve clinical outcomes. The study is approved by the Ethics Committee (S-20160124) and the Danish Data Protecting Agency (2008-58-035). Study findings will be disseminated through peer-reviewed journals, patient associations and presentations at international conferences.Trial registration numberNCT03173144; Pre-results.
Databáze:	OpenAIRE
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