The effect of 5,5- Diethylbarbituric acid on the biosynthesis of anthracyclines inStreptomyces galilaeus
| Autor: | E. Královcová, Vanĕk Z, Margita Blumauerová |
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| Rok vydání: | 1977 |
| Předmět: |
Chemical Phenomena
Mutant Anthraquinones Barbital Microbiology Streptomyces chemistry.chemical_compound Biosynthesis medicine Glycosides Mycelium chemistry.chemical_classification Barbituric acid Strain (chemistry) biology Glycoside General Medicine biology.organism_classification Anti-Bacterial Agents Oxygen Chemistry chemistry Biochemistry Barbiturates Fermentation medicine.drug |
| Zdroj: | Folia Microbiologica. 22:182-188 |
| ISSN: | 1874-9356 0015-5632 |
| DOI: | 10.1007/bf02885599 |
| Popis: | 5,5-Diethylbarbituric acid (barbital) stimulates the production of anthracycline antibiotics called galirubins in Streptomyces galilaeus in dependence on the strain, concentration and cultivation conditions. The stimulation is more pronounced (up to 300%) in the low-producing strain than in the production mutant. Under conditions of limited aeration the effect of barbital is increased in both strains. In the production strain barbital narrows the spectrum of metabolites produced. Higher barbital concentrations inhibit growth of the mycelium of both strains and decrease the formation of free anthracyclinones. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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