Constituents from Polygonatum sibiricum and their inhibitions on the formation of advanced glycosylation end products
| Autor: | Hong-Hua Wu, Juan Wang, Yan-Tong Xu, Yan Zhu, Dong-Yan Liu, Cheng-Shu Lu |
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| Rok vydání: | 2016 |
| Předmět: |
Glycation End Products
Advanced Polygonatum sibiricum Stereochemistry Saponin Pharmaceutical Science 01 natural sciences Analytical Chemistry chemistry.chemical_compound Functional food Drug Discovery Ic50 values Humans Nuclear Magnetic Resonance Biomolecular Pharmacology chemistry.chemical_classification biology Traditional medicine Molecular Structure 010405 organic chemistry Liliaceae Organic Chemistry Polygonatum General Medicine Saponins biology.organism_classification 0104 chemical sciences Rhizome 010404 medicinal & biomolecular chemistry Complementary and alternative medicine chemistry Molecular Medicine Advanced glycation end-product Drugs Chinese Herbal |
| Zdroj: | Journal of Asian natural products research. 18(7) |
| ISSN: | 1477-2213 |
| Popis: | A new saponin, isonarthogenin 3-O-β-d-glucopyranosyl-(1→4)-β-d-galactopyranoside (1), together with twelve known compounds, were isolated from the rhizomes of Polygonatum sibiricum. The structures of these compounds were elucidated by analysis of their 1D/2D NMR and MS data. Among them, phenol compounds 4–7 and 9–10 showed significant inhibitions against the formation of advanced glycosylation end products, with IC50 values of 0.091 ± 0.0021, 0.10 ± 0.041, 0.014 ± 0.0027, 0.11 ± 0.011, 0.13 ± 0.045, and 0.055 ± 0.019 μM, respectively. The results will promote exploiting potential medicinal use of these compounds in the prevention of diabetic complications and supporting Polygonatum sibiricum as a functional food for healthy and medicinal diet. |
| Databáze: | OpenAIRE |
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