The Microbiome Factor in Drug Discovery and Development
| Autor: | James R. Brown, Andrea Nuzzo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Drug
0303 health sciences Drug discovery business.industry Microbiota media_common.quotation_subject Late stage General Medicine 010501 environmental sciences Toxicology Bioinformatics 01 natural sciences Clinical trial 03 medical and health sciences Drug Development Drug development Drug Discovery Animals Humans Medicine Microbiome business 030304 developmental biology 0105 earth and related environmental sciences media_common |
| Zdroj: | Chemical Research in Toxicology. 33:119-124 |
| ISSN: | 1520-5010 0893-228X |
| Popis: | Here we review recent studies that illustrate three areas where the microbiome directly impacts drug development: (1) microbial effects on drug safety and efficacy, (2) the effects of drugs on causing collateral restructuring of microbiome communities, and (3) the potential side-effects of novel therapies targeting the microbiome. On the basis of the findings of these and other studies, we advocate the systematic incorporation of microbiome analyses in early to late stage clinical trials as a strategy to increase the overall success rate of the drug discovery and development process. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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