Liposomal prednisolone inhibits vascular inflammation and enhances venous outward remodeling in a murine arteriovenous fistula model
| Autor: | T.C. Rothuizen, Josbert M. Metselaar, Ton J. Rabelink, Taisiya Bezhaeva, Joris I. Rotmans, Anouk Wezel, Paul H.A. Quax, Alexander L. Vahrmeijer, Margreet R. de Vries, Anton Jan van Zonneveld, Floris P. R. Verbeek, ChunYu Wong |
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| Přispěvatelé: | Faculty of Science and Technology, Biomaterials Science and Technology |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Pathology medicine.medical_specialty Intimal hyperplasia CD3 Complex Prednisolone 030232 urology & nephrology Arteriovenous fistula Inflammation Vascular Remodeling 030204 cardiovascular system & hematology Matrix metalloproteinase Article 03 medical and health sciences 0302 clinical medicine medicine Animals Vascular Patency RNA Messenger cardiovascular diseases Cells Cultured Multidisciplinary business.industry Macrophages Tissue Inhibitor of Metalloproteinases IR-103924 medicine.disease Matrix Metalloproteinases In vitro Pathophysiology Mice Inbred C57BL Disease Models Animal METIS-321011 Arteriovenous Fistula Liposomes Cytokines Leukocyte Common Antigens Jugular Veins medicine.symptom business medicine.drug |
| Zdroj: | Scientific reports, 6:30439. Nature Publishing Group Scientific Reports, 6 Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Arteriovenous fistulas (AVF) for hemodialysis access have a 1-year primary patency rate of only 60%, mainly as a result of maturation failure that is caused by insufficient outward remodeling and intimal hyperplasia. The exact pathophysiology remains unknown, but the inflammatory vascular response is thought to play an important role. In the present study we demonstrate that targeted liposomal delivery of prednisolone increases outward remodeling of the AVF in a murine model. Liposomes accumulate in the post-anastomotic area of the venous outflow tract in which the vascular pathology is most prominent in failed AVFs. On a histological level, we observed a reduction of lymphocytes and granulocytes in the vascular wall. In addition, a strong anti-inflammatory effect of liposomal prednisolone on macrophages was demonstrated in vitro. Therefore, treatment with liposomal prednisolone might be a valuable strategy to improve AVF maturation. |
| Databáze: | OpenAIRE |
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