Feasibility and toxicity of CCNU therapy in elderly patients with glioblastoma multiforme
| Autor: | Johannes A. Hainfellner, Peter Birner, Maria Piribauer, Monika Killer, Daniela Prayer, Karl Rössler, Karl Ungersböck, Barbara Fazeny-Dörner, Karin Dieckmann, Christine Marosi, Manfred Muhm, Thomas Czech |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Stereotactic biopsy Multivariate analysis medicine.medical_treatment Lomustine medicine Humans Pharmacology (medical) Prospective Studies Antineoplastic Agents Alkylating Aged Aged 80 and over Pharmacology Chemotherapy medicine.diagnostic_test Brain Neoplasms business.industry Palliative Care Female sex Middle Aged Prognosis medicine.disease Surgery Survival Rate Radiation therapy Oncology Concomitant Toxicity Disease Progression Feasibility Studies Female Radiotherapy Adjuvant Glioblastoma business |
| Zdroj: | Anti-Cancer Drugs. 14:137-143 |
| ISSN: | 0959-4973 |
| DOI: | 10.1097/00001813-200302000-00007 |
| Popis: | In our institution, 103 glioblastoma multiforme (GBM) patients aged from 55 to 83 years were treated since November 1994 as follows. All patients underwent surgical intervention (gross total resection, n = 35; subtotal resection, n = 38; stereotactic biopsy, n = 30). Subsequently all patients were offered radiotherapy and chemotherapy with CCNU. Results were as follows: 101 patients started radiotherapy, 93 patients completed it (96% of the patients aged65 years and 85% of the patientsor =65 years). All patients received at least 1 cycle of chemotherapy (median 3 cycles). Chemotherapy-associated toxicity was generally mild, more pronounced in females and did not increase with age. Median time to progression was 10.5+/-3.2 months for the patients65 years and 5.1+/-1 months for patientsor =65 years. median overall survival was 17.5+/-3.8 months in patients65 years and 8.6+/-1 months in patientsor =65 years (p0.0001). In multivariate analysis, age and female sex remained independent prognostic factors. Our data indicate that a treatment concept including concomitant radio- and chemotherapy is feasible even in elderly patients with GBM. |
| Databáze: | OpenAIRE |
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