Offspring preterm birth and birth size are related to long-term risk of maternal diabetes
| Autor: | Per Ovesen, Niels Jørgen Secher, Anders Gorst-Rasmussen, Klara Vinsand Naver, Søren Lundbye-Christensen, Lisbeth Nilas |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Epidemiology Offspring Birth weight Denmark Gestational Age Risk Assessment Pregnancy Risk Factors Diabetes mellitus medicine Birth Weight Humans Prospective Studies Registries Proportional Hazards Models Obstetrics business.industry Hazard ratio Infant Newborn Gestational age medicine.disease Logistic Models Diabetes Mellitus Type 2 Socioeconomic Factors Population Surveillance Cohort Gestation Premature Birth Female business Cohort study Follow-Up Studies |
| Zdroj: | Naver, K V, Secher, N J, Ovesen, P G, Gorst-Rasmussen, A, Lundbye-Christensen, S & Nilas, L 2013, ' Offspring preterm birth and birth size are related to long-term risk of maternal diabetes ', European Journal of Epidemiology, vol. 28, no. 5, pp. 427-32 . https://doi.org/10.1007/s10654-013-9805-z |
| DOI: | 10.1007/s10654-013-9805-z |
| Popis: | The aim of the study is to investigate the association between gestational age, birth size, and the long-term risk of maternal diabetes. We conducted a nation-wide prospective follow-up study of the cohort of all Danish women with a singleton delivery in 1982/1983 (index delivery) and no history of diabetes (n = 100,669). Registries were used to extract information on patients with a hospital or outpatient diagnosis of diabetes, subsequent deliveries, and death/emigration in the period from the index delivery until the end of 2006. The association between the maternal risk of diabetes and the index gestational age and index offspring birth size (birth weight adjusted for gestational age) was investigated by using Cox proportional hazards regression models stratified according to young (≤33 years) and old age (>33 years). During a median follow-up period of 24 years, 2,021 women (2.0 %) were diagnosed as having diabetes. The risk of maternal diabetes was positively associated with increasing index birth size and negatively associated with increasing duration of index gestation in both age strata. Among young women, the highest hazard ratios were found for the exposure category of large index offspring birth size (adjusted HR 9.0, 95 % CI 6.17-13.12) and a preterm delivery at 32-37 weeks (adjusted HR 2.22, 95 % CI 1.46-3.40). Offspring preterm birth and large size for gestational age at birth are associated with increased risk of maternal diabetes. |
| Databáze: | OpenAIRE |
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