Placental mitochondrial DNA content and placental abruption: a pilot study
| Autor: | Sixto E. Sanchez, Daniel A. Enquobahrie, Chunfang Qiu, Karin Hevner, Michelle A. Williams |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Mitochondrial DNA medicine.medical_specialty Enfermedades mitocondriales Embarazo Placenta Pilot Projects ADN mitocondrial Biology DNA Mitochondrial General Biochemistry Genetics and Molecular Biology Andrology Young Adult Desprendimiento prematuro de la placenta Pregnancy Odds Ratio medicine Humans Abruptio Placentae Medicine(all) Placental abruption Biochemistry Genetics and Molecular Biology(all) Obstetrics Placental mitochondrial DNA Case-control study Placentation General Medicine Odds ratio medicine.disease 3. Good health Biomarcadores Real-time polymerase chain reaction medicine.anatomical_structure Mitochondrial biogenesis Case-Control Studies Female Mitochondrial dysfunction Biomarkers Research Article |
| Zdroj: | BMC Research Notes Repositorio Académico USMP Universidad San Martín de Porres-USMP USMP-Institucional Universidad de San Martín de Porres instacron:USMP |
| ISSN: | 1756-0500 |
| Popis: | Background Mitochondrial biogenesis and adequate energy production are important for embryogenesis and placentation. Previous studies documented alterations in maternal blood mitochondrial DNA (mtDNA) copy number—a marker of mitochondrial dysfunction—in pregnancies complicated by placental abruption. To further understand the role of mitochondrial dysfunction in the pathogenesis of placental abruption, we conducted a pilot study using placental specimen collected from 103 placental abruption cases and 102 non-abruption controls. Real-time quantitative polymerase chain reaction (PCR) was used to assess the relative copy number of mtDNA in DNA extracted from placental samples collected immediately after delivery. Logistic regression procedures were used to estimate adjusted odds ratios (OR) and 95 % confidence intervals (CI). Results Higher odds of placental abruption was observed with increasing mtDNA copy number (p value for trend = 0.05). The odds of placental abruption was elevated among women who delivered placentas with higher mtDNA copy number (≥120.5, the median) as compared with those with lower values ( |
| Databáze: | OpenAIRE |
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