Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice
Autor: | Yong Cheol Shin, Ah Jeong Kim, Seong-Gyu Ko, Sang Mi Woo, Sung Gook Cho, Youn Kyung Choi, Yee Jin Yun |
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Rok vydání: | 2015 |
Předmět: |
0301 basic medicine
Leptin Male Cancer Research medicine.medical_treatment Adipose tissue Biochemistry STAT3 Mice 0302 clinical medicine Weight loss media_common biology digestive oral and skin physiology Interleukin Articles Anorexia JAK1 Oncology Adipose Tissue 030220 oncology & carcinogenesis Molecular Medicine medicine.symptom Signal Transduction STAT3 Transcription Factor medicine.medical_specialty media_common.quotation_subject Antineoplastic Agents 03 medical and health sciences Internal medicine Genetics medicine Animals Interleukin 6 Molecular Biology Chemotherapy business.industry Interleukin-6 Appetite Janus Kinase 1 Disease Models Animal 030104 developmental biology Endocrinology biology.protein Cisplatin business Drugs Chinese Herbal Sip-jeon-dea-bo-tang |
Zdroj: | Molecular Medicine Reports |
ISSN: | 1791-3004 |
Popis: | Despite its therapeutic advantages, chemotherapy can also cause adverse effects, including anorexia and loss of appetite. Although numerous patients with cancer have been reported to suffer from anorexia during or following chemotherapy, treatment options for anorexia remain to be determined. In Asian countries, traditional medicines are widely used to treat problems with appetite; sip-jeon-dea-bo-tang (SJDBT) is one of those medicines used for the treatment of anorexia. The present study demonstrated that SJDBT ameliorated cisplatin-induced anorexia. In a mouse model of chemotherapy-induced anorexia, oral administration of SJDBT prevented the cisplatin-induced reduction of food intake, inhibiting weight loss. The results of multiplex assays showed that SJDBT only altered the levels of interleukin (IL)-6 and leptin in the serum and fat tissue. In addition, SJDBT maintained the serum leptin level and increased the serum IL-6 level, whereas cisplatin reduced the levels of both serum leptin and IL‑6. Furthermore, SJDBT was revealed to increase the levels of leptin and IL-6 in the fat tissue by activating the JAK1/STAT3 signaling pathway. In conclusion, the present results revealed that SJDBT ameliorated cisplatin-induced anorexia, suggesting its usefulness in the prevention of anorexia during chemotherapy. |
Databáze: | OpenAIRE |
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