| Autor: |
Tian-Li Wang, Ie-Ming Shih, Kala Visvanathan, Lori Sokoll, Jianhua Xuan, Jinghua Gu, Jen-Chun Kuan, Jin-Gyoung Jung, Ren-Chin Wu, Hiroyasu Kashima, Yusuke Kobayashi |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1078-0432.22461533.v1 |
| Popis: |
Supplementary Tables 1-3, Supplementary Figures 1-7. Supplementary Table 1: Oligonucleotide primers used for qRT-PCR analysis. Supplementary Table 2: GSEA enrichment of KEGG functional pathways in lovastatin-regulated genes. Supplementary Table 3: Lovastatin affects expression of genes in glycolysis/gluconeogenesis pathway. Supplementary Figure 1: Daily administration of lovastatin prevents tumor growth in mogp-TAg transgenic mice. Supplementary Figure 2: Body weight and serum levels of cholesterol and triglyceride in mogp-TAg, SKOV3-IP, and OVCAR5 mouse tumor models. Supplementary Figure 3: Atorvastatin treatment delays growth of ovarian tumor xenografts. Supplementary Figure 4: Statin treatment increases transcript levels of LC3A and LC3B. Supplementary Figure 5: Scheme of the mevalonate pathway. Supplementary Figure 6: Applying GGPP or FPP as a single agent does not affect ovarian cancer cell proliferation. Supplementary Figure 7: Real-time qRT-PCR confirms knockdown efficiency of each siRNA. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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