Effects on arterial intima of saline infusions
| Autor: | M Sanchez, James F. Mowbray, Eric W. Fonkalsrud, Theodore X. O'Connell |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Graft Rejection
Moderate to severe Pathology medicine.medical_specialty medicine.medical_treatment Transplantation Heterologous Arterial Occlusive Diseases Sodium Chloride Antibodies Arterial Intima Blood Transfusion Autologous Species Specificity Transplantation Immunology Parenchyma medicine Animals Transplantation Homologous Infusions Parenteral Saline biology business.industry Immune Sera Osmolar Concentration Hydrogen-Ion Concentration Perfusion Transplantation Carotid Arteries medicine.anatomical_structure Microscopy Electron Scanning biology.protein Surgery Rabbits Antibody business Artery |
| Zdroj: | Journal of Surgical Research. 16:197-203 |
| ISSN: | 0022-4804 |
| Popis: | Infusion of arteries with normal physiologic saline produces immediate topographical changes in the infused artery that are demonstrable with the scanning electron microscope. When examined 1 month after saline infusion, the arteries had moderate to severe initial thickening. The intimal thickening produced by humoral transplantation antibodies was increased by a prior infusion of the artery with saline. Infusion with autologous serum produced little or no intimal thickening, and prior infusion with autologous serum did not significantly affect the thickening produced by humoral antibodies. It is suggested that arterial damage occurring during organ perfusion prior to transplantation increases significantly the production of obliterative vascular lesions. Perfusates must be selected that not only protect parenchymal function but that also do not produce significant vascular damage. |
| Databáze: | OpenAIRE |
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