Transient nigral ubiquinone depletion after single MPTP administration in mice
| Autor: | Orlando Ghirardi, Luciano Angelucci, M.T. Ramacci, R.G. Fariello, A. Peschechera |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Ubiquinol
medicine.medical_specialty Ratón Pyridines Ubiquinone Dopamine Central nervous system Substantia nigra Biology Cellular and Molecular Neuroscience chemistry.chemical_compound Mice Internal medicine medicine Animals Vitamin E Respiratory system Pharmacology MPTP Substantia Nigra medicine.anatomical_structure Endocrinology nervous system chemistry Biochemistry 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine Toxicity Female Transient (oscillation) |
| Zdroj: | Neuropharmacology. 26(12) |
| ISSN: | 0028-3908 |
| Popis: | The administration of a single injection of 30 mg/kg MPTP to mice produces at 1 hr, a transient significant decrease of the reduced ubiquinol Q10 in the substantia nigra that is normalized afterwards. This suggests a transient stress imposed by MPTP (or more likely MPP+) in the mitochondrial respiratory and/or oxidoreducing system, located in close proximity to the NADH system. |
| Databáze: | OpenAIRE |
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