Cutaneous Sporotrichosis Treated with Photodynamic Therapy: An in Vitro and in Vivo Study
| Autor: | Michael R. Hamblin, Elena Andres-Ciriano, Antonio Rezusta, M. Carmen Alejandre, Luis Charlez, Yolanda Gilaberte, Carmen Aspiroz, Blanca Fortuño, María José Revillo |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Pathology Itraconazole medicine.medical_treatment Biomedical Engineering Case Report Photodynamic therapy Methyl aminolevulinate In vivo medicine Humans Sporothrix schenckii Radiology Nuclear Medicine and imaging Cells Cultured Aged Photosensitizing Agents biology Sporotrichosis Sporothrix biology.organism_classification medicine.disease Dermatology Photochemotherapy Terbinafine Female medicine.drug |
| Zdroj: | Photomedicine and Laser Surgery. 32:54-57 |
| ISSN: | 1557-8550 1549-5418 |
| DOI: | 10.1089/pho.2013.3590 |
| Popis: | Background: Sporotrichosis is a fungal infection caused by Sporothrix schenckii complex, usually restricted to the skin, subcutaneous cellular tissue, and adjacent lymphatic vessels. Antimicrobial photodynamic therapy (aPDT) could be a good alternative to manage localized, superficial infections. Case report: A 65-year-old African woman was diagnosed with a fixed cutaneous sporotrichosis on her left arm, treated with itraconazol and oral terbinafine with partial improvement. Topical 16% methyl aminolevulinate (MAL, Metvix®)-PDT was used without success. Methods: An in vitro photoinactivation test with the isolated microorganism revealed phenothiazinium salts to be more effective than MAL. Conclusions: PDT with intralesional 1% methylene blue (MB) in combination with intermittent low doses of itraconazole obtained complete microbiological and clinical response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|