Biomarkers of Cardiovascular Remodeling in Patients on Peritoneal Dialysis
| Autor: | Damir Rebić, Senija Rasić, Snežana Unčanin, Amina Valjevac, Aida Hamzić-Mehmedbašić |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Carotid Artery Diseases Male medicine.medical_specialty medicine.medical_treatment Renal function Nitric Oxide Muscle hypertrophy Peritoneal dialysis medicine.artery Diabetes mellitus Internal medicine Humans Medicine Prospective Studies Common carotid artery Prospective cohort study Aged Ultrasonography Dialysis adequacy Endothelin-1 Ventricular Remodeling business.industry Middle Aged medicine.disease Endothelin 1 Diabetes Mellitus Type 2 Nephrology Cardiology Kidney Failure Chronic Female Hypertrophy Left Ventricular business Peritoneal Dialysis Biomarkers Follow-Up Studies |
| Zdroj: | American Journal of Nephrology. 39:92-99 |
| ISSN: | 1421-9670 0250-8095 |
| DOI: | 10.1159/000358261 |
| Popis: | Objectives: The purpose of this study was to determine endothelin (ET)-1 and nitric oxide (NO) serum concentration levels at baseline and after 1 year of peritoneal dialysis (PD) treatment. A further aim was to evaluate the association between ET-1 and NO with parameters of echocardiography and the common carotid artery (CCA) ultrasound, and to assess their impact on cardiovascular remodeling. We also aimed to evaluate the influence of dialysis adequacy and residual renal function (RRF) on cardiovascular remodeling. Methods: This study included 40 PD patients in whom we measured serum ET-1 and NO concentrations, echocardiography and CCA ultrasound parameters. Results: ET-1 decreased and NO serum concentration levels increased (p < 0.01) after 12 months of PD treatment compared to baseline values. Left ventricular (LV) hypertrophy was observed in 77.5% of patients at baseline with significant reduction in LV mass index (LVMI), CCA intima media thickness (IMT) and plaque score after 12 months of PD treatment (p < 0.001). The dialysis adequacy and RRF were significantly associated with LVMI and CCA IMT after 12 months on PD. Conclusion: In our study, ET-1 significantly decreased while NO increased during PD treatment and both were independently related to the cardiovascular remodeling parameters in PD patients. |
| Databáze: | OpenAIRE |
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