Mechanosensing by the nucleus: From pathways to scaling relationships
| Autor: | Jerome Irianto, Dennis E. Discher, Sangkyun Cho |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Proteomics
0301 basic medicine Nuclear Envelope Reviews Review Biology Mechanotransduction Cellular Models Biological 03 medical and health sciences 0302 clinical medicine Protein structure Databases Genetic medicine Animals Humans Phosphorylation Mechanotransduction Nuclear protein Transcription factor Cell Nucleus Gene Expression Profiling Computational Biology Nuclear Proteins Cell Biology Chromatin Assembly and Disassembly Cell biology Cell nucleus 030104 developmental biology medicine.anatomical_structure Gene Expression Regulation Stress Mechanical Nucleus 030217 neurology & neurosurgery Lamin |
| Zdroj: | The Journal of Cell Biology |
| ISSN: | 1540-8140 0021-9525 |
| Popis: | Cho, Irianto, and Discher review emerging mechanisms of nuclear mechanosensing and propose through meta-analyses of published data the universality of mechanosensing pathways. The nucleus is linked mechanically to the extracellular matrix via multiple polymers that transmit forces to the nuclear envelope and into the nuclear interior. Here, we review some of the emerging mechanisms of nuclear mechanosensing, which range from changes in protein conformation and transcription factor localization to chromosome reorganization and membrane dilation up to rupture. Nuclear mechanosensing encompasses biophysically complex pathways that often converge on the main structural proteins of the nucleus, the lamins. We also perform meta-analyses of public transcriptomics and proteomics data, which indicate that some of the mechanosensing pathways relaying signals from the collagen matrix to the nucleus apply to a broad range of species, tissues, and diseases. |
| Databáze: | OpenAIRE |
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