Neuromodulation for the Treatment of Heart Rhythm Disorders
| Autor: | Marat Fudim, Joseph P. Mathew, Nathan H. Waldron, Jonathan P. Piccini |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
SNS sympathetic nervous system lcsh:Diseases of the circulatory (Cardiovascular) system Heart rhythm disorders RDN renal denervation AERP atrial effective refractory period 030204 cardiovascular system & hematology STATE-OF-THE-ART REVIEW 0302 clinical medicine OSA - Obstructive sleep apnea VT ventricular tachycardia atrial fibrillation AF - Atrial fibrillation Atrial fibrillation ganglionated plexi ICD implantable cardioverter-defibrillator Neuromodulation (medicine) 3. Good health neuromodulation Cardiology cardiovascular system ANS autonomic nervous system VF ventricular fibrillation Cardiology and Cardiovascular Medicine VNS vagal nerve stimulation POAF post-operative atrial fibrillation medicine.medical_specialty AF atrial fibrillation HRV heart rate variability arrhythmia 03 medical and health sciences Internal medicine SGB stellate ganglion blockade medicine cardiovascular diseases SCS spinal cord stimulation OSA obstructive sleep apnea VF - Ventricular fibrillation business.industry PVI pulmonary vein isolation autonomic nervous system ventricular arrhythmias AGP autonomic ganglionic plexus LLVNS low-level vagal nerve stimulation medicine.disease Autonomic nervous system 030104 developmental biology lcsh:RC666-701 VT - Ventricular tachycardia business CABG coronary artery bypass grafting |
| Zdroj: | JACC: Basic to Translational Science JACC: Basic to Translational Science, Vol 4, Iss 4, Pp 546-562 (2019) |
| ISSN: | 2452-302X |
| Popis: | Highlights • Derangement of autonomic nervous signaling is an important contributor to cardiac arrhythmogenesis. • Modulation of autonomic nervous signaling holds significant promise for the prevention and treatment of cardiac arrhythmias. • Further clinical investigation is necessary to establish the efficacy and safety of autonomic modulatory therapies in reducing cardiac arrhythmias. Summary There is an increasing recognition of the importance of interactions between the heart and the autonomic nervous system in the pathophysiology of arrhythmias. These interactions play a role in both the initiation and maintenance of arrhythmias and are important in both atrial and ventricular arrhythmia. Given the importance of the autonomic nervous system in the pathophysiology of arrhythmias, there has been notable effort in the field to improve existing therapies and pioneer additional interventions directed at cardiac-autonomic targets. The interventions are targeted to multiple and different anatomic targets across the neurocardiac axis. The purpose of this review is to provide an overview of the rationale for neuromodulation in the treatment of arrhythmias and to review the specific treatments under evaluation and development for the treatment of both atrial fibrillation and ventricular arrhythmias. Central Illustration |
| Databáze: | OpenAIRE |
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