Prognostic value of peripheral blood T lymphocyte subsets in clear cell renal cell carcinoma
Autor: | Hao Zhang, Shuchang Huang, Xi Chu, Jinhua Wang, Yihong Zhou, Yu-Xin Tang, Yingbo Dai, Dong Jiang, Wenjie Cheng, Min Liu |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Multivariate analysis biology business.industry Proportional hazards model Urology CD3 CD4-CD8 Ratio Value (computer science) medicine.disease Gastroenterology Log-rank test 03 medical and health sciences Clear cell renal cell carcinoma 030104 developmental biology 0302 clinical medicine Reproductive Medicine 030220 oncology & carcinogenesis Internal medicine medicine biology.protein Original Article business CD8 |
Zdroj: | Transl Androl Urol |
ISSN: | 2223-4691 |
Popis: | BACKGROUND: To date, few studies have evaluated the role of peripheral blood T lymphocyte subsets in patients with clear cell renal cell carcinoma (ccRCC). Here we measured the levels of peripheral blood T lymphocyte subsets and evaluated its prognostic value in ccRCC. METHODS: Data from 122 patients with RCC from January 2018 to January 2020 were collected. Preoperative peripheral blood T lymphocyte subsets and medical records were analyzed. Kaplan-Meier cures and log rank test were used for analyzing overall survival (OS). Univariate and multivariate survival analyses were underwent by performing the Cox proportional hazards models. Correlations were tested by Pearson’s correlation analysis. RESULTS: Of 122 patients, a total of 80 ccRCC patients was enrolled. Patients with low CD3(+) T cells and low CD4(+)/CD8(+) ratio displayed a worse OS than patients with high CD3(+) T cells and high CD4(+)/CD8(+) ratio (P=0.029 and 0.002, respectively). Multivariate analyses showed CD3(+) T cells and CD4(+)/CD8(+) ratio were independent predictive factors for the OS (HR: 0.295, 95% CI, 0.091–0.956; P=0.042 and HR: 0.244, 95% CI, 0.065–0.920; P=0.037, respectively). Moreover, NLR negatively correlated with both levels of CD3(+) T cells and CD4(+)/CD8(+) ratio (P |
Databáze: | OpenAIRE |
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