Familial malignant blood disease in the county of Jämtland, Sweden
| Autor: | Mikael Eriksson, Ingmar Bergström |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pediatrics
medicine.medical_specialty Chronic lymphocytic leukemia Disease medicine.disease_cause Polycythemia vera hemic and lymphatic diseases Internal medicine Heredity medicine Humans Multiple myeloma Sweden Acute leukemia Leukemia Myeloproliferative Disorders Hematology business.industry General Medicine medicine.disease Lymphoproliferative Disorders Pedigree Immunology business |
| Zdroj: | European Journal of Haematology. 38:241-245 |
| ISSN: | 1600-0609 0902-4441 |
| Popis: | In a material of 942 patients with malignant hematological disease, encompassing all diagnosed cases in the county of Jamtland in Sweden during a 22‐yr period, 36 families with multiple cases of such disease were found. Approximately 5% of the patients have at least one close relative who also suffers from a malignant hematological disease. An especially strong familial occurrence was found in the group of chronic lymphoproliferative diseases and it is concluded that this tendency comprises all diseases in the group, i.e. chronic lymphocytic leukemia, multiple myeloma and malignant lymphoma. In some families several cases of acute leukemia were present, and suggestions concerning immunological disturbances are made. In the group of chronic myeloproliferative diseases familial factors do not seem to play an important. part, with the possible exception of polycythemia vera. Both heredity and common environmental agents must be considered as possible etiologic factors. (Less) |
| Databáze: | OpenAIRE |
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