Recommendations to standardize preanalytical confounding factors in Alzheimer's and Parkinson's disease cerebrospinal fluid biomarkers: an update
| Autor: | Armand Perret-Liaudet, Marcel M. Verbeek, Brit Mollenhauer, Lucilla Parnetti, Andrea Urbani, Charlotte E. Teunissen, Esen Saka, Antonio Bertolotto, Eugeen Vanmechelen, Sylvain Lehmann, Pieter Jelle Visser, Harald Hampel, Anja Hviid Simonsen, Nathalie Le Bastard, José Luis Molinuevo, Marta Del Campo, Niels Kruse, Javier Sáez-Valero, Sebastiaan Engelborghs, Elisabeth Kapaki |
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| Přispěvatelé: | Neurology, Laboratory Medicine, NCA - Neurodegeneration, Psychiatrie & Neuropsychologie, RS: MHeNs School for Mental Health and Neuroscience, Clinical sciences |
| Rok vydání: | 2012 |
| Předmět: |
Oncology
Pathology Parkinson's disease Clinical Biochemistry High variability Disease Specimen Handling/instrumentation 0302 clinical medicine Cerebrospinal fluid Drug Discovery guidelines Medicine(all) 0303 health sciences Settore BIO/12 Confounding Temperature Parkinson Disease Alzheimer's disease 3. Good health alpha-Synuclein Biological Markers Peptide Fragments/cerebrospinal fluid early diagnosis Alzheimer Disease/diagnosis medicine.medical_specialty Peptide Fragments Amyloid beta-Peptides Humans Alzheimer Disease Specimen Handling Phase Transition tau Proteins Operating procedures DCN MP - Plasticity and memory CSF 03 medical and health sciences Internal medicine mental disorders medicine Biomarkers/cerebrospinal fluid DCN NN - Brain networks and neuronal communication 030304 developmental biology standard operating procedures alpha-Synuclein/cerebrospinal fluid business.industry Biochemistry (medical) Parkinson Disease/diagnosis tau Proteins/cerebrospinal fluid Guideline medicine.disease Amyloid beta-Peptides/cerebrospinal fluid preanalytical factors Csf biomarkers recommendations Human medicine business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Biomarkers in Medicine, 6, 419-30 Biomarkers in Medicine, 6, 4, pp. 419-30 del Campo, M, Mollenhauer, B, Bertolotto, A, Engelborghs, S, Hampel, H, Simonsen, A H, Kapaki, E, Kruse, N, Le Bastard, N, Lehmann, S, Molinuevo, J L, Parnetti, L, Perret-Liaudet, A, Saez-Valero, J, Saka, E, Urbani, A, Vanmechelen, E, Verbeek, M, Visser, P J & Teunissen, C E 2012, ' Recommendations to standardize preanalytical confounding factors in Alzheimer's and Parkinson's disease cerebrospinal fluid biomarkers: an update ', Biomarkers in medicine, vol. 6, no. 4, pp. 419-430 . https://doi.org/10.2217/BMM.12.46 Biomarkers in medicine, 6(4), 419-430. Future Medicine Ltd. Digital.CSIC. Repositorio Institucional del CSIC instname Biomarkers in medicine Biomarkers in Medicine, 6(4), 419-430. Future Medicine Ltd. |
| ISSN: | 1752-0363 |
| DOI: | 10.2217/BMM.12.46 |
| Popis: | Sáez-Valero, Javier, [et al.] Early diagnosis of neurodegenerative disorders such as Alzheimers (AD) or Parkinsons disease (PD) is needed to slow down or halt the disease at the earliest stage. Cerebrospinal fluid (CSF) biomarkers can be a good tool for early diagnosis. However, their use in clinical practice is challenging due to the high variability found between centers in the concentrations of both AD CSF biomarkers (A42, total tau and phosphorylated tau) and PD CSF biomarker (α-synuclein). Such a variability has been partially attributed to different preanalytical procedures between laboratories, thus highlighting the need to establish standardized operating procedures. Here, we merge two previous consensus guidelines for preanalytical confounding factors in order to achieve one exhaustive guideline updated with new evidence for A42, total tau and phosphorylated tau, and α-synuclein. The proposed standardized operating procedures are applicable not only to novel CSF biomarkers in AD and PD, but also to biomarkers for other neurodegenerative disorders. © 2012 Future Medicine Ltd. |
| Databáze: | OpenAIRE |
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