SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity
| Autor: | Gabrielle T. Belz, E. Bridie Clemens, Katherine Kedzierska, Nicos A. Nicola, Lukasz Kedzierski, Sandra E. Nicholson, Nicola L. Bird, Benjamin T. Kile |
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| Rok vydání: | 2015 |
| Předmět: |
Chemokine
medicine.medical_treatment Immunology Orthomyxoviridae Suppressor of Cytokine Signaling Proteins CD8-Positive T-Lymphocytes medicine.disease_cause Virus Immunophenotyping Mice Orthomyxoviridae Infections Cell Movement Immunity medicine Influenza A virus Animals Immunology and Allergy Lung Mice Knockout Mice Inbred BALB C biology Cell Biology Acquired immune system biology.organism_classification Virology Cytokine biology.protein Cytokines Immunologic Memory CD8 |
| Zdroj: | Immunology & Cell Biology. 93:909-913 |
| ISSN: | 1440-1711 0818-9641 |
| DOI: | 10.1038/icb.2015.55 |
| Popis: | Suppressor of cytokine signaling (SOCS) proteins are key regulators of innate and adaptive immunity. Mice lacking functional SOCS4 are hypersusceptible to primary infection with influenza A virus (IAV), displaying dysregulated pro-inflammatory cytokine and chemokine production in the lungs, delayed viral clearance and impaired trafficking of influenza-specific CD8(+) T cells to the site of infection. Therefore, we postulated that SOCS4 is a critical regulator of anti-viral immunity. Unexpectedly, SOCS4 was not required for CD8(+) T-cell memory generation, nor was it required to efficiently recall those cells in response to secondary IAV infection. Wild-type or SOCS4-deficient mice primed and re-challenged with serologically different influenza strains, did not show differences in susceptibility to IAV and cleared the virus from the lungs at the same rate. We have not observed differences in trafficking or numbers of IAV-specific cells, numbers of resident memory T cells or in cytokine profiles in lungs of infected animals. Our data show that despite an impaired primary immune response in Socs4(R108X/R108X) mice, SOCS4 is dispensable for an efficient recall response to influenza virus infection. |
| Databáze: | OpenAIRE |
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