Structures of diphospho-myo-inositol pentakisphosphate and bisdiphospho-myo-inositol tetrakisphosphate from Dictyostelium resolved by NMR analysis
| Autor: | U Thiel, R Eujen, C M Weisshuhn, Tim Laussmann, Günter Vogel |
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| Rok vydání: | 1996 |
| Předmět: |
Steric effects
Magnetic Resonance Spectroscopy Molecular Structure biology Chemistry Stereochemistry Inositol Phosphates Metabolite Phosphorus Isotopes Cell Biology biology.organism_classification Biochemistry Dictyostelium Phosphotransferase Inositol pentakisphosphate chemistry.chemical_compound Animals Inositol Enantiomer Molecular Biology Research Article Hydrogen |
| Zdroj: | Biochemical Journal. 315:715-720 |
| ISSN: | 1470-8728 0264-6021 |
| DOI: | 10.1042/bj3150715 |
| Popis: | Diphospho-myo-inositol phosphates (PP-InsP5 and bis-PP-InsP4) were isolated from Dictyostelium in order to clarify the precise positional isomerism by two-dimensional 1H/31P-NMR analysis. The diphosphorylated inositol phosphates are 4-PP-Ins(1,2,3,5,6)P5 and 4,5-bis-PP-Ins(1,2,3,6)P4 or their corresponding enantiomers. The vicinal arrangement of the diphospho groups with its steric and electrostatic constraints possibly qualifies bis-PP-InsP4 as a metabolite with high phosphate-group-transfer potential in phosphotransferase reactions. |
| Databáze: | OpenAIRE |
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