Combined functional MRI and tractography to demonstrate the connectivity of the human primary motor cortex in vivo
Autor: | Gareth J. Barker, Claudia A. M. Wheeler-Kingshott, John S. Duncan, Geoffrey J. M. Parker, Mark R. Symms, P A Boulby, Afraim Salek-Haddadi, Maxime Guye |
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Rok vydání: | 2003 |
Předmět: |
Adult
Male Epilepsy Frontal Lobe Cognitive Neuroscience Pyramidal Tracts Statistical parametric mapping behavioral disciplines and activities White matter Imaging Three-Dimensional Thalamus Reference Values Cerebellum Parietal Lobe Image Processing Computer-Assisted medicine Humans Dominance Cerebral Brain Mapping Pyramidal tracts Resting state fMRI Brain Neoplasms Motor Cortex Human brain Middle Aged Evoked Potentials Motor Magnetic Resonance Imaging Frontal Lobe Diffusion Magnetic Resonance Imaging medicine.anatomical_structure nervous system Neurology Female Neural Networks Computer Nerve Net Primary motor cortex Psychology Neuroscience Algorithms Tractography Diffusion MRI |
Zdroj: | NeuroImage. 19:1349-1360 |
ISSN: | 1053-8119 |
Popis: | In this study, we combined advanced MR techniques to explore primary motor cortex (M1) connectivity in the human brain. We matched functional and anatomical information using motor functional MRI (fMRI) and white matter tractography inferred from diffusion tensor imaging (DTI). We performed coregistered DTI and motor task fMRI in 8 right-handed healthy subjects and in 1 right-handed patient presenting with a left precentral tumour. We used the fast-marching tractography (FMT) algorithm to define 3D connectivity maps within the whole brain, from seed points selected in the white matter adjacent to the location of the maximum of fMRI activation. Connectivity maps were then anatomically normalised and analysed using statistical parametric mapping software (SPM99) allowing group comparisons (left versus right hemisphere in control subjects and patient versus control subjects). The results demonstrated, in all control subjects, strong connections from M1 to the pyramidal tracts, premotor areas, parietal cortices, thalamus, and cerebellum. M1 connectivity was asymmetric, being more extensive in the dominant hemisphere. The patient had differences in M1 connectivity from the control group. Thus, fMRI-correlated DTI-FMT is a promising tool to study the structural basis of functional networks in the human brain in vivo. |
Databáze: | OpenAIRE |
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