Adjuvant-induced arthritis induces c-Fos chronically in neurons in the hippocampus
| Autor: | Jeff Carter, Tracy Osredkar, Bethany Reese, Cheri Lubahn, Jill Schaller, T.C. Der, Natalie Ruff, Dianne Lorton, S. Flowers, Denise L. Bellinger, Stephen Evelsizer |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pathology medicine.medical_specialty medicine.medical_treatment Immunology Arthritis Gene Expression c-Fos Hippocampus Arthritis Rheumatoid medicine Immunology and Allergy Hippocampus (mythology) Animals Cognitive decline Saline Neurons biology business.industry Dentate gyrus Chronic pain medicine.disease Arthritis Experimental Immunohistochemistry Rats nervous system Neurology Rats Inbred Lew Rheumatoid arthritis biology.protein Neurology (clinical) business Proto-Oncogene Proteins c-fos |
| Zdroj: | Journal of neuroimmunology. 230(1-2) |
| ISSN: | 1872-8421 |
| Popis: | Chronic pain, sickness behaviors, and cognitive decline are symptoms in rheumatoid arthritis. In the adjuvant-induced arthritis Lewis rat model, we examined the dynamics of c-Fos expression in the hippocampus, a brain region important for these symptoms. Brain sections were stained for c-Fos using immunohistochemistry. c-Fos-positive nuclei were counted in CA1, CA2, CA3 and the dentate gyrus of the dorsal hippocampi from rats receiving no treatment or base-of-the-tail injections of (1 or 2) incomplete or complete Freund's adjuvant (low- or high-dose), (3), Mycobacterium butyricum cell wall suspended in saline, or (4) saline, and sacrificed 4, 14, 21, or 126days post-immunization. Disease severity was evaluated by dorsoplantar foot pad widths and X-ray analysis. We report sustained dose- and subfield-dependent c-Fos expression with arthritis, but transient expression in nonarthritic groups, suggesting long-term genomic changes in rheumatoid arthritis that may be causal for behavioral changes, adaptation to chronic pain and/or cognitive decline associated with disease. |
| Databáze: | OpenAIRE |
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