PAI-1, the Plasminogen System, and Skeletal Muscle
| Autor: | Fasih Ahmad Rahman, Matthew P. Krause |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Aging Review Muscle Development Muscular Dystrophies Extracellular matrix lcsh:Chemistry chemistry.chemical_compound 0302 clinical medicine Fibrosis therapeutics Medicine Muscular dystrophy lcsh:QH301-705.5 Spectroscopy pathophysiology diabetes exercise General Medicine Extracellular Matrix Computer Science Applications Cell biology medicine.anatomical_structure 030220 oncology & carcinogenesis Plasminogen activator inhibitor-1 plasminogen activator inhibitor-1 muscular dystrophy Cell fate determination Catalysis Inorganic Chemistry 03 medical and health sciences Plasminogen Activator Inhibitor 1 Diabetes Mellitus Animals Humans Physical and Theoretical Chemistry skeletal muscle Muscle Skeletal Molecular Biology Inflammation business.industry Regeneration (biology) Organic Chemistry Skeletal muscle medicine.disease Protein Structure Tertiary 030104 developmental biology chemistry lcsh:Biology (General) lcsh:QD1-999 regeneration plasminogen system business Plasminogen activator |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 7066, p 7066 (2020) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | The plasminogen system is a critical proteolytic system responsible for the remodeling of the extracellular matrix (ECM). The master regulator of the plasminogen system, plasminogen activator inhibitor-1 (PAI-1), has been implicated for its role in exacerbating various disease states not only through the accumulation of ECM (i.e., fibrosis) but also its role in altering cell fate/behaviour. Examination of PAI-1 has extended through various tissues and cell-types with recent investigations showing its presence in skeletal muscle. In skeletal muscle, the role of this protein has been implicated throughout the regeneration process, and in skeletal muscle pathologies (muscular dystrophy, diabetes, and aging-driven pathology). Needless to say, the complete function of this protein in skeletal muscle has yet to be fully elucidated. Given the importance of skeletal muscle in maintaining overall health and quality of life, it is critical to understand the alterations—particularly in PAI-1—that occur to negatively impact this organ. Thus, we provide a comprehensive review of the importance of PAI-1 in skeletal muscle health and function. We aim to shed light on the relevance of this protein in skeletal muscle and propose potential therapeutic approaches to aid in the maintenance of skeletal muscle health. |
| Databáze: | OpenAIRE |
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