Hepatitis autoinmune y anticuerpos anti-Ro positivos. ¿Alguna relación?
| Autor: | J. Ferrando Ginestar, M. Bustamante Balén, A. Borghol Hariri, A.Jiménez Sánchez, S.Mery Rams, S. Rull Segura, F. Devesa Jordà, J. Ortuño Cortés, J.A.Ramos Ñíguez |
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| Rok vydání: | 2003 |
| Předmět: |
Autoimmune disease
Systemic lupus erythematosus biology Anti-nuclear antibody Hepatology business.industry Gastroenterology Connective tissue Autoimmune hepatitis medicine.disease medicine.anatomical_structure Antigen immune system diseases Immunology medicine biology.protein Antibody business Ribonucleoprotein |
| Zdroj: | Gastroenterología y Hepatología. 26:475-479 |
| ISSN: | 1578-9519 0210-5705 |
| DOI: | 10.1157/13051929 |
| Popis: | Antinuclear antibodies (ANA) are considered to be markers of autoimmune disease. Several specific reactivities of ANA are known, among them the Ro (SS-a) complex. Although the presence of anti-Ro antibodies is widely known in systemic connective tissue diseases such as lupus erythematous or Sjogren's syndrome, few studies have attempted to link this finding with autoimmune hepatitis (AIH). We present a case of acute AIH in a 55-year-old woman who tested positive for anti-Ro 60 kD antibodies. The Ro (SS-A) antigen is a complex ribonucleoprotein whose structure is still the subject of debate. Two fractions, of 50 and 60 kD, have been identified. A review of the literature revealed frequencies of 21-34% for anti-Ro 52 kD and of 9-13-6% for anti-Ro 60 kD in AIH. Although no relationship has been demonstrated between this complex and the etiopathogenic mechanisms or clinical patterns of AIH, we propose that multicenter investigations with large series should be performed before the possible involvement of anti-Ro antibodies in these diseases is definitively ruled out. |
| Databáze: | OpenAIRE |
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