Myocardial Regional Interstitial Fibrosis is Associated With Left Intra-Ventricular Dyssynchrony in Patients With Heart Failure: A Cardiovascular Magnetic Resonance Study
| Autor: | Fu-Tien Chiang, Mao-Yuan M. Su, Wen Yih Issac Tseng, Ling Ping Lai, Jiunn Lee Lin, Lian-Yu Lin, Juey-Jen Hwang, Jyh-Ming Jimmy Juang, Cho-Kai Wu, Yi-Chih Wang |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Heart Ventricles Endomyocardial fibrosis 030204 cardiovascular system & hematology Interstitial fibrosis Ventricular Function Left Article 030218 nuclear medicine & medical imaging 03 medical and health sciences Ventricular Dysfunction Left 0302 clinical medicine Internal medicine medicine Humans In patient Ventricular dyssynchrony Aged Heart Failure Multidisciplinary medicine.diagnostic_test business.industry Magnetic resonance imaging Middle Aged medicine.disease Endomyocardial Fibrosis Magnetic Resonance Imaging Pathophysiology Heart failure Cardiology Female business Heart failure with preserved ejection fraction |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep20711 |
| Popis: | Left ventricular (LV) dyssynchrony is associated with poor prognosis in patients with heart failure (HF). The mechanisms leading to LV dyssynchrony are not fully elucidated. This study evaluates whether myocardium regional variation in interstitial fibrosis is associated with LV dyssynchrony. Forty-two patients with systolic heart failure (SHF), 76 patients with heart failure with preserved ejection fraction (HFpEF) and 20 patients without HF received cardiovascular magnetic resonance imaging (MRI) study. LV was divided into 18 segments by short-axis view. In each segment, regional extracellular volume fraction (ECV) and the time taken to reach minimum regional volume (Tmv) were derived. Intra-LV dyssynchrony were represented by maximum difference (Dysyn_max) and standard deviation (Dysyn_sd) of all Tmv. The results showed that among the covariates, only age (1.87, 95% CI: 0.61–3.13, p = 0.004) and ECV (3.77, 95% CI: 2.72–4.81, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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