A hesperetin derivative plays a role in immunoregulatory effect on human macrophages
| Autor: | Jian-li Ma, Chun Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Cell Survival
THP-1 Cells Phagocytosis medicine.medical_treatment Interleukin-1beta bcl-X Protein Blood drug concentration Nitric Oxide 03 medical and health sciences chemistry.chemical_compound Immune system Immunity In vivo medicine Humans Immunologic Factors Cell Proliferation 0303 health sciences Interleukin-6 Chemistry Hesperidin Macrophages 030302 biochemistry & molecular biology Hesperetin General Medicine In vitro Cell biology Cytokine |
| Zdroj: | Cellular and Molecular Biology. 65:43-47 |
| ISSN: | 1165-158X 0145-5680 |
| DOI: | 10.14715/cmb/2019.65.4.7 |
| Popis: | The immune system is an important physiological defense system. Its balance and stability are closely related to the body's health. Once the immune system loses its dynamic balance, the immune response will be blocked, which will lead to the occurrence of various diseases. Hesperetin is a kind of natural flavonoids extracted from citrus fruits of Rutaceae and it has many pharmacological activities. However, its water solubility and liposolubility are poor, and it is easy to be quickly metabolized in vivo, so it is difficult to maintain high blood drug concentration. Therefore, its derivative (HES) was found by structural modification. In this study, THP-1 cells were used as experimental model to investigate the immunomodulatory effect of HES in vitro. The results showed that HES participates in immune response by enhancing phagocytosis of macrophages to promote the release of NO, IL-6 and IL-1β, and enhancing immunity by up-regulating the expression of Bcl-2 and Bcl-XL proteins. This study provides a theoretical and practical basis for the development of HES as an immunomodulator in the future. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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