Longitudinal comparison of the developing gut virome in infants and their mothers
| Autor: | William A. Walters, Andrea C. Granados, Catherine Ley, Scot Federman, Doug Stryke, Yale Santos, Thomas Haggerty, Alicia Sotomayor-Gonzalez, Venice Servellita, Ruth E. Ley, Julie Parsonnet, Charles Y. Chiu |
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| Rok vydání: | 2023 |
| Předmět: |
bacteriophages
principal component analysis Immunology Mothers microbiome Microbiology metagenomic sequencing Virology Humans 2.2 Factors relating to the physical environment Aetiology maternal virome parechovirus Pediatric Virome Prevention SURPI alpha diversity Perinatal Period - Conditions Originating in Perinatal Period infant gut virome Good Health and Well Being Medical Microbiology Viruses Metagenome picornaviruses Female beta diversity Parasitology Metagenomics Infection microviruses |
| Zdroj: | Cell host & microbe, vol 31, iss 2 |
| ISSN: | 1931-3128 |
| Popis: | The human gut virome and its early life development are poorly understood. Prior studies have captured single-point assessments with the evolution of the infant virome remaining largely unexplored. We performed viral metagenomic sequencing on stool samples collected longitudinally from a cohort of 53 infants from age 2weeks to 3 years (80.7 billion reads), and from their mothers (9.8 billion reads) to examine and compare viromes. The asymptomatic infant virome consisted of bacteriophages, nonhuman dietary/environmental viruses, and human-host viruses, predominantly picornaviruses. In contrast, human-host viruses were largely absent from the maternal virome. Previously undescribed, sequence-divergent vertebrate viruses were detected in the maternal but not infant virome. As infants aged, the phage component evolved to resemble the maternal virome, but by age 3, the human-host component remained dissimilar from the maternal virome. Thus, early life virome development is determined predominantly by dietary, infectious, and environmental factors rather than direct maternal acquisition. |
| Databáze: | OpenAIRE |
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