Two cases of primary solitary fibrous tumor in the pelvis resected using laparoscopic surgery
| Autor: | Fusao Sumiyama, Yoko Sekita-Hatakeyama, Hisanori Miki, Chiho Ohbayashi, Yuki Matsui, Madoka Hamada, Yuki Matsumi, Mitsugu Sekimoto, Toshinori Kobayashi, Hiroaki Kurokawa, Mitsuaki Ishida, Kinta Hatakeyama |
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| Rok vydání: | 2020 |
| Předmět: |
Laparoscopic surgery
medicine.medical_specialty Solitary fibrous tumor medicine.medical_treatment Rectum Fusion gene Article 03 medical and health sciences 0302 clinical medicine Biopsy medicine Pelvis STAT6 Pelvic tumor integumentary system medicine.diagnostic_test business.industry Pelvic cavity medicine.disease Appendicitis medicine.anatomical_structure 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Surgery Radiology business |
| Zdroj: | International Journal of Surgery Case Reports |
| ISSN: | 2210-2612 |
| Popis: | Highlights • The preoperative diagnosis of the solitary fibrous tumors is difficult irrespective of usage of the various imaging modalities. • The technique of lateral pelvic lymph node dissection is useful for the extirpation of SFTs around the obturator cavity. • Immunohistochemical examination of the specimens revealed STAT6 (+) and the NAB2-STAT6 fusion gene was detected in one case. Background We report two resected cases of solitary fibrous tumors (SFT) that were accidentally found in the pelvic cavity. Case presentation Case 1 was a 54-year-old male. A colonoscopy for the examination of intestinal polyps revealed an extramural tumor in the right anterior wall of the low rectum. A preoperative MRI showed a well-demarcated T1 low and T2 mixed intensity extramural tumor (53 × 36 mm) located right lateral to the low rectum and behind the seminal vesicle. Laparoscopic surgery was successful for tumor extirpation. Immunohistochemical examination of the specimen revealed STAT6 (+) and CD34 (+) cells, a Ki67 positivity of 7–8%, a mitotic index of 4–5/50 HPF, and a diagnosis of SFT. There was no recurrence 29 months after surgery. Using RT-PCR and sequencing, we detected the NAB2-STAT6 fusion gene but the locus of genomic inversion was not detected. Case 2 was a 43-year-old male that received conservative treatment for appendicitis. A CT scan accidentally revealed a tumor of 40 mm of length in the left obturator area. A MRI revealed a well-demarcated T1 and T2 high intensity tumor. The patient underwent surgical biopsy. Immunohistochemical examination of the biopsy revealed STAT6 (+) and CD34 (+) cells, Ki67 positive cells < 1%, and a diagnosis of SFT. We could not detect the NAB2-STAT6 fusion gene in the extirpated tumor. Conclusions Two cases of pelvic SFT were diagnosed by immunohistochemical examination, RT-PCR and sequencing and successfully resected by laparoscopic surgery. |
| Databáze: | OpenAIRE |
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