Partial pressure of oxygen and partial pressure of carbon dioxide of perfluorocarbon liquid during partial liquid ventilation: their regional difference and their dependence on tidal volume and positive end-expiratory pressure level
| Autor: | Tokujiro Uchida, Kuninori Yokoyama, Koichi Nakazawa, Koshi Makita |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Liquid Ventilation
Partial Pressure medicine.medical_treatment Positive pressure Critical Care and Intensive Care Medicine pCO2 Positive-Pressure Respiration chemistry.chemical_compound Intensive care Tidal Volume medicine Animals Prospective Studies Respiratory system Tidal volume Positive end-expiratory pressure Mechanical ventilation Analysis of Variance Fluorocarbons Perflubron business.industry Hemodynamics Carbon Dioxide respiratory system respiratory tract diseases Oxygen chemistry Anesthesia Rabbits business circulatory and respiratory physiology |
| Zdroj: | Intensive Care Medicine. 27:36-41 |
| ISSN: | 1432-1238 0342-4642 |
| DOI: | 10.1007/s001340000706 |
| Popis: | Objective: To investigate the regional partial pressure of oxygen (PO2) and partial pressure of carbon dioxide (PCO2) of the perfluorocarbon liquid (PpfcO2, PpfcCO2) during partial liquid ventilation (PLV). Design: Prospective, controlled study. Setting: A research laboratory at a university medical center. Subjects: Thirteen Japanese white rabbits. Interventions: After the tracheostomy, PLV was started with perflubron (15 ml/kg) following saline lung lavage. Fractional inspired oxygen (FIO2) was 1.0, respiratory rate was 30 bpm and tidal volume (VT) was 30 ml. Two epidural catheters (18 gauge) were inserted from the rubber diaphragm interposed in the respiratory circuit to sample perflubron. One catheter was inserted into the left lower lobe bronchus and placed at 5–6 cm distal from the carina (DISTAL). The other one was inserted at the tip of the endotracheal tube (PROXIMAL). Then the effect of the larger VT (50 ml) or positive end-expiratory pressure (PEEP; 10 cmH2O) to the gas tension in perflubron was examined. Measurements and main results: (1) In the lower VT (30 ml) with 0 cmH2O PEEP, DISTAL PpfcO2 was significantly lower than PROXIMAL PpfcO2 (265±72 vs 386±47 mmHg, p |
| Databáze: | OpenAIRE |
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