Cryo-EM of the native structure of the calcium release channel/ryanodine receptor from sarcoplasmic reticulum

Autor:	C. Chadwick, Michael Radermacher, T. Wagenknecht, M. Inui, Joachim Frank, Robert A. Grassucci, Sidney Fleischer
Rok vydání:	1992
Předmět:	Protein Conformation Cryo-electron microscopy Biophysics Muscle Proteins chemistry.chemical_element Calcium Biophysical Phenomena 03 medical and health sciences 0302 clinical medicine Freezing medicine Animals Receptors Cholinergic Receptor 030304 developmental biology 0303 health sciences Lagomorpha Voltage-dependent calcium channel biology Ryanodine receptor Endoplasmic reticulum Skeletal muscle Ryanodine Receptor Calcium Release Channel biology.organism_classification Microscopy Electron Sarcoplasmic Reticulum medicine.anatomical_structure Biochemistry chemistry Calcium Channels Rabbits 030217 neurology & neurosurgery Research Article
Zdroj:	Biophysical Journal. 61(4):936-940
ISSN:	0006-3495
DOI:	10.1016/s0006-3495(92)81900-8
Popis:	The native structure of the calcium release channel (ryanodine receptor) from rabbit skeletal muscle has been analyzed in two dimensions from electron micrographs of frozen hydrated specimens. Within a resolution of 3.0 nm there is excellent agreement between the structure as seen in vitreous water and in negative stained specimens. Features seen in the three-dimensional reconstruction of the negatively stained channel can be identified in the projection of the unstained receptor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b665f87666af114a1b1d004a0bcd2ca8 Zobrazit plný text záznamu