MicroRNA expression profiling in bone marrow: Implications in hematological malignancies
| Autor: | Ana Costa, Catarina Osorio, Sérgio Dias |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Gene Expression Profiling
General Medicine Disease Biology medicine.disease_cause Bioinformatics Applied Microbiology and Biotechnology Gene expression profiling Mice MicroRNAs Haematopoiesis medicine.anatomical_structure Bone Marrow Hematologic Neoplasms microRNA Gene expression Biomarkers Tumor medicine Animals Humans Molecular Medicine Bone marrow Carcinogenesis Function (biology) Oligonucleotide Array Sequence Analysis |
| Zdroj: | Biotechnology Journal. 4:88-97 |
| ISSN: | 1860-7314 1860-6768 |
| DOI: | 10.1002/biot.200800194 |
| Popis: | MicroRNA (miRNA) have been recently attributed a crucial role in the control of gene expression in numerous physiological and pathological processes including growth, differentiation and even oncogenesis. Besides detailed mechanistic studies on their generation and function, there has been a great deal of interest in the study of miRNA as surrogate markers of disease. Numerous studies have attempted to define miRNA profiles as predictors of disease outcome, or for the classification/diagnosis of different pathologies. In the present review, we summarize the main studies describing the involvement of miRNA in bone marrow (BM) diseases and in normal BM function during hematopoiesis. |
| Databáze: | OpenAIRE |
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