Circulating miRNAs in Successful and Unsuccessful Aging. A Mini-review
| Autor: | Giuseppe Cammarata, Simona Taverna, Alessia Lo Curto, Tiziana Di Chiara, Giovanni Duro, Giuseppina Candore |
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| Přispěvatelé: | Giuseppe Cammarata, Giovanni Duro, Tiziana Di Chiara, Alessia Lo Curto, Simona Taverna, Giuseppina Candore |
| Rok vydání: | 2019 |
| Předmět: |
Parabiosis
Inflammation exosomes Disease Biology Bioinformatics Exosome Mice 03 medical and health sciences 0302 clinical medicine age-related diseases Drug Discovery microRNA medicine Animals Humans Circulating MicroRNA Epigenetics 030304 developmental biology Settore MED/04 - Patologia Generale Pharmacology 0303 health sciences Regeneration (biology) aging miR-126 Phenotype Circulating miRNAs aging exosome inflammation mediators age-related diseases miR-21-5p miR-126 inflammation mediators Models Animal miRNAs miR-21-5p medicine.symptom 030217 neurology & neurosurgery |
| Zdroj: | Current pharmaceutical design (2019). info:cnr-pdr/source/autori:Giuseppe Cammarata; Giovanni Duro; Tiziana Di Chiara; Alessia Lo Curto; Simona Taverna; Giuseppina Candore./titolo:Circulating miRNAs in Successful and Unsuccessful Aging. A Mini-review/doi:/rivista:Current pharmaceutical design (Print)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume |
| ISSN: | 1381-6128 |
| DOI: | 10.2174/1381612825666191119091644 |
| Popis: | Aging is a multifactorial process that affects the organisms at genetic, molecular and cellular levels. This process modifies several tissues with a negative impact on cells physiology, tissues and organs functionality, altering their regeneration capacity. The chronic low-grade inflammation typical of aging, defined as inflammaging, is a common biological factor responsible for the decline and beginning of the disease in age. A murine parabiosis model that combines the vascular system of old and young animals, suggests that soluble factors released by young individuals may improve the regenerative potential of old tissue. Therefore, circulating factors have a key role in the induction of aging phenotype. Moreover, lifestyle can influence the physiological status of multiple organs, via epigenetic mechanisms. Recently, microRNAs are considered potential sensors of aging. |
| Databáze: | OpenAIRE |
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