Tumor Cyclooxygenase-2 Gene Suppresses Local Immune Responses in Patients with Hepatocellular Carcinoma
| Autor: | Yasuaki Hirooka, Tomohiro Ozaki, Kuniyuki Katano, Masahide Ikeguchi, Youji Hukumoto, Sachico Matsumoto, Masashi Inoue, Takashi Tanida, Kanenori Endo, Akemi Iwamoto, Masayuki Ataka |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Carcinoma Hepatocellular T cell medicine.medical_treatment CD8-Positive T-Lymphocytes Biology Disease-Free Survival Gene Expression Regulation Enzymologic 03 medical and health sciences 0302 clinical medicine Immune system Gene expression Biomarkers Tumor medicine Humans Cytotoxic T cell Aged Neoplasm Staging Aged 80 and over 030219 obstetrics & reproductive medicine Reverse Transcriptase Polymerase Chain Reaction Liver Neoplasms Immunosuppression General Medicine Middle Aged HCCS Prognosis medicine.disease Gene Expression Regulation Neoplastic medicine.anatomical_structure Oncology Cyclooxygenase 2 Hepatocellular carcinoma Cancer research Female 030217 neurology & neurosurgery CD8 |
| Zdroj: | Tumori Journal. 92:130-133 |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.1177/030089160609200208 |
| Popis: | Aims and Background In several neoplastic diseases including hepatocellular carcinoma (HCC) immunosuppression is correlated with disease stage, progression and outcome. Moreover, recent studies have demonstrated that cyclooxygenase-2 (COX-2) enhances tumor growth in HCCs. The present study analyzed the correlation between local immune responses and COX-2 gene expression levels in patients with primary HCCs. Methods Fresh tissues were obtained from 59 patients who underwent resection of an HCC. The COX-2 gene expression levels were quantified by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) and compared with the CD8+ T cell densities detected by immunohistochemistry. Results COX-2 gene expression was detected in 35 of the 59 tumors. The CD8+ T cell density in COX-2-expressing tumors (6.1 cells/high-power field (HPF), x200 magnification) was suppressed compared with that in non-COX-2-expressing tumors (13.6 cells/HPF, P = 0.009). Tumor COX-2 gene expression was associated with a poorer disease-free survival rate. Conclusions Elevation of the tumor COX-2 level is correlated with the suppression of local immune responses in HCCs, suggesting that COX-2 plays a role in early tumor recurrence in the residual liver in patients after HCC resection. |
| Databáze: | OpenAIRE |
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